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To construct a strong classifier ensemble, base classifiers should be accurate and diverse. However, there is no uniform standard for the definition and measurement of diversity. This work proposes a learners' interpretability diversity (LID) to measure the diversity of interpretable machine learners. It then proposes a LID-based classifier ensemble. Such an ensemble concept is novel because: 1) interpretability is used as an important basis for diversity measurement and 2) before its training, the difference between two interpretable base learners can be measured. To verify the proposed method's effectiveness, we choose a decision-tree-initialized dendritic neuron model (DDNM) as a base learner for ensemble design. We apply it to seven benchmark datasets. The results show that the DDNM ensemble combined with LID obtains superior performance in terms of accuracy and computational efficiency compared to some popular classifier ensembles. A random-forest-initialized dendritic neuron model (RDNM) combined with LID is an outstanding representative of the DDNM ensemble.
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http://dx.doi.org/10.1109/TNNLS.2023.3290203 | DOI Listing |
Proc Natl Acad Sci U S A
September 2025
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202.
Retinal ganglion cells (RGCs) are highly compartmentalized neurons whose long axons serve as the sole connection between the eye and the brain. In both injury and disease, RGC degeneration occurs in a similarly compartmentalized manner, with distinct molecular and cellular responses in the axonal and somatodendritic regions. The goal of this study was to establish a microfluidic-based platform to investigate RGC compartmentalization in both health and disease states.
View Article and Find Full Text PDFJ Vis Exp
August 2025
Department of Cell Biology and Imaging, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University;
Examining circadian synaptic plasticity requires housing mice under different lighting conditions (light/dark cycle, LD 12:12, and constant darkness, DD), providing access to running wheels, and sacrificing them at four defined time points within 24 h-at the beginning and middle of the day/subjective day and at the beginning and middle of the night/subjective night. Brains are then properly fixed for transmission electron microscopy (TEM). The barrel cortex, with its precise somatotopic organization, provides an ideal model for such analysis.
View Article and Find Full Text PDFJ Cell Biol
November 2025
Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.
Two major protein recycling pathways have emerged as key regulators of enduring forms of synaptic plasticity, such as long-term potentiation (LTP), yet how these pathways are recruited during plasticity is unknown. Phosphatidylinositol-3-phosphate (PI(3)P) is a key regulator of endosomal trafficking and alterations in this lipid have been linked to neurodegeneration. Here, using primary hippocampal neurons, we demonstrate dynamic PI(3)P synthesis during chemical induction of LTP (cLTP), which drives coordinate recruitment of the SNX17-Retriever and SNX27-Retromer pathways to endosomes and synaptic sites.
View Article and Find Full Text PDFMol Ther Nucleic Acids
September 2025
Center of Emphasis in Neuroscience, Department of Molecular and Translational Medicine, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX 79905, USA.
Parkinson's disease (PD) is a debilitating neurodegenerative condition. Synaptic dysfunctions are associated with the onset and progressive neurodegeneration exhibited in PD. Healthy, active synapses are a prerequisite for non-pathological neurotransmission.
View Article and Find Full Text PDFFront Biosci (Landmark Ed)
August 2025
Division of Life Sciences and Department of Life Science, Graduate School, CHA University, 13488 Seongnam-si, Gyeonggi-do, Republic of Korea.
Background: Parkinson's disease (PD) is characterized by a progressive decline in dopaminergic neurons within the substantia nigra (SN). Although its underlying cause has yet to be fully elucidated, accumulating evidence suggests that neuroinflammation contributes substantially to disease development. Treatment strategies targeting neuroinflammation could improve PD outcomes.
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