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The syndrome of inappropriate ADH-secretion (SIADH) is a common cause of low sodium levels with diverse aetiology. Here, we report a case of a 41 years old male patient diagnosed with SIADH and a good response to Tolvaptan therapy. Of interest, as a potential unique cause, magnetic resonance imaging revealed a micronodular structure in the posterior pituitary, while no other common cause of SIADH could be identified. Hence, to the best of our knowledge, this is the first case of a Tolvaptan-responsive SIADH associated with a pituitary micronodular structure.
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http://dx.doi.org/10.1055/a-2093-1002 | DOI Listing |
Palliat Med Rep
August 2025
Division of Palliative Medicine, Mayo Clinic Arizona, Phoenix, Arizona, USA.
Airway obstruction is a distressing and potentially life-threatening complication in patients with advanced head and neck cancers, particularly squamous cell carcinoma (SCC) of the pharynx. This case highlights the clinical, ethical, and interdisciplinary complexities involved in managing airway compromise in the context of progressive disease and limited treatment options. A 75-year-old man with recurrent SCC of the soft palate, nasopharynx, oropharynx, and hypopharynx, recently initiated on pembrolizumab and radiation therapy, presented with dysphagia, stridor, and intermittent tumor bleeding.
View Article and Find Full Text PDFJ Med Virol
September 2025
Department of Pathology, West China Hospital, Sichuan University, Chengdu, China.
Systemic chronic active Epstein-Barr virus disease (sCAEBVD) can primarily involve skeletal muscle to form CAEBV-myopathy (CAEBV-M), which may resemble idiopathic inflammatory myopathies (IIMs). This study reports an 11-patient, 10-year cohort of CAEBV-M to summarize clinicoseropathologic features. CAEBV-M typically affects young adults (median: 29 years), with universal limb swelling, frequent disseminated muscle involvement (73%), and systemic symptoms like fever (82%), splenomegaly (82%), and hemophagocytic lymphohistiocytosis (55%).
View Article and Find Full Text PDFIntern Med
September 2025
Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan.
A 60-year-old woman with rheumatoid arthritis and an impaired consciousness was referred to our hospital. Prior to transfer, the patient underwent intensified immunosuppressive therapy under a diagnosis of rheumatoid vasculitis that had developed in her buttocks. Upon hospitalization, she developed severe multiorgan failure and hemophagocytic syndrome.
View Article and Find Full Text PDFAnn Med Surg (Lond)
September 2025
Department of Neurosurgery, Rutgers, Robert Wood Johnson Medical School & University, Hospital, New Brunswick, NJ, USA.
Introduction: There have been growing efforts to identify predictors of Cerebral Vasospasm to facilitate earlier diagnosis and establish patient predictive models. This review discusses the implications of serum electrolytes, glycemic indices, and inflammatory markers in predicting the occurrence of aSAH-induced CV.
Methods: The literature was reviewed across PubMed, Scopus, Web of Science, Google scholars, the National Center for Biotechnology Information, the Centers for Disease Control and Prevention, the World Health Organization, and the National Institutes of Health.
Mol Genet Genomics
September 2025
Department of Bioscience, Faculdade de Odontologia de Piracicaba, Universidade de Campinas (FOP/UNICAMP), Piracicaba, SP, Brazil.
Variant classification in genetic testing often culminates in "uncertain" calls, known as variants of uncertain significance (VUS), which remain a major clinical challenge. Among the established criteria for variant classification, population allele frequency (AF) is fundamental, yet under-representation of non-European groups hinders accurate interpretation. In this study, we evaluated the impact of population-specific AF on the reclassification of VUS and conflicting variants in hereditary cancer genes.
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