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Purpose: NOTCH3 is increasingly implicated for its oncogenic role in many malignancies, including meningiomas. While prior work has linked NOTCH3 expression to higher-grade meningiomas and treatment resistance, the metabolic phenotype of NOTCH3 activation remains unexplored in meningioma.

Methods: We performed single-cell RNA sequencing on NOTCH3 + human meningioma cell lines.

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Bridging Planarian Bioassays and AOP-Based Environmental Assessment: Toward Mechanistic Insights into Pollutant-Induced Disruptions.

Environ Res

September 2025

School of Geography, Earth & Environmental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom. Electronic address:

Human activities have introduced a wide range of contaminants into aquatic ecosystems, posing substantial ecological and health risks. Robust bioindicators are essential for accurately predicting these impacts. Since the early 1980s, planarians-freshwater flatworms known for their remarkable regenerative ability and neurologically relevant system-have been used in ecotoxicology, witnessing renewed scientific interest post-2010.

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Purpose Of Review: This review examines how metabolic reprogramming drives fibrosis and immune dysregulation in systemic sclerosis (SSc), emphasizing the role of nutrient-sensing and energy pathways in disease progression.

Recent Findings: SSc is characterized by a shift from catabolic to anabolic metabolism, defined by reduced AMP-activated protein kinase (AMPK) and enhanced mechanistic target of rapamycin complex 1 (mTORC1) signaling. This promotes biosynthetic activity, with upregulated glycolysis supplying substrates for collagen production and supporting pro-inflammatory immune cell polarization.

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Osteoarthritis (OA) is a multifactorial, mechano-inflammatory joint disorder characterized by cartilage degradation, synovial inflammation, and subchondral bone remodeling. Despite its high prevalence and significant impact on quality of life, no disease-modifying treatments have been approved. In many other disease areas, advanced omics technologies are impacting the development of advanced therapies.

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Single-cell omics reveal the mechanisms of traditional Chinese medicines.

Phytomedicine

August 2025

Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China. Electronic address:

Background: Traditional Chinese medicines (TCMs) have a long-standing history and diverse applications. However, their complex multi-component compositions and intricate mechanisms of action pose significant challenges for modern scientific investigation. Addressing these complexities requires advanced techniques capable of dissecting cellular and molecular interactions with high resolution.

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