Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Neuronal activity drives alterations in gene expression within neurons, yet how it directs transcriptional and epigenomic changes in neighboring astrocytes in functioning circuits is unknown. We found that neuronal activity induces widespread transcriptional up-regulation and down-regulation in astrocytes, highlighted by the identification of as an activity-inducible astrocyte gene that encodes neuromodulator transporter Slc22a3 and regulates sensory processing in the mouse olfactory bulb. Loss of astrocytic Slc22a3 reduced serotonin levels in astrocytes, leading to alterations in histone serotonylation. Inhibition of histone serotonylation in astrocytes reduced the expression of γ-aminobutyric acid (GABA) biosynthetic genes and GABA release, culminating in olfactory deficits. Our study reveals that neuronal activity orchestrates transcriptional and epigenomic responses in astrocytes while illustrating new mechanisms for how astrocytes process neuromodulatory input to gate neurotransmitter release for sensory processing.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10874521 | PMC |
| http://dx.doi.org/10.1126/science.ade0027 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
High-grade astrocytoma with piloid features resected with an exoscopic supracerebellar infratentorial approach: illustrative case.
J Neurosurg Case Lessons
September 2025
Department of Neurosurgery, Fleming Neuroscience Institute, Allentown, Pennsylvania.
Background: High-grade astrocytoma with piloid features (HGAP) was recently added to the WHO 2021 CNS classification system among the group of circumscribed astrocytic gliomas. These tumors present with high-grade piloid histology with similarities to glioblastoma. HGAPs in the pineal region become particularly challenging due to its deep location and proximity to deep venous structures, the midbrain, and the thalamus.
View Article and Find Full Text PDFDevelopment of the SCI-BodyMap-Measuring Mental Body Representations in Adults With Spinal Cord Injury: Protocol for Item Generation, Reliability, and Validity Testing.
JMIR Res Protoc
September 2025
Division of Physical Therapy and Rehabilitation Science, Department of Family Medicine and Community Health, Medical School, University of Minnesota-Twin Cities, Minneapolis, MN, United States.
Background: Approximately 69% of Americans with spinal cord injury (SCI) have neuropathic pain. Research suggests that impairments in mental body representations (MBRs; ie, representations of the body in the brain) likely contribute to neuropathic pain. Clinical trials in adults with SCI, focused on restoring MBR, led to improvements in sensation and movement as well as neuropathic pain relief.
View Article and Find Full Text PDFWild bats hunt insects faster under lit conditions by integrating acoustic and visual information.
Proc Natl Acad Sci U S A
September 2025
Department of Evolutionary Ecology, Leibniz Institute for Zoo and Wildlife Research, Berlin 10315, Germany.
Animals can improve their decision-making abilities by integrating information from multiple senses, which is especially beneficial when living in fluctuating environments. However, understanding how wild predators may use multimodal sensing when hunting prey in split-second interactions remains largely unexplored. As nocturnal hunters, bats rely on echolocation to navigate and to locate evasive prey, yet they have retained functional vision, despite the associated costs.
View Article and Find Full Text PDFImpact of stress and coping strategies on quality of life in hematological malignancies: A cross-sectional study.
PLoS One
September 2025
Department of Clinical Nursing Teaching and Research Section, School of Nursing, Hebei Medical University, Shijiazhuang, China.
Background And Aims: While perceived stress and coping strategies have been established as significant determinants of quality of life (QoL) in patients with solid malignancies, their impact on hematological malignancy population have not been fully elucidated. This study aimed to examine how perceived stress and medical coping strategies interact with sociodemographic factors to influence QoL in patients with hematologic malignancies.
Methods: The study, involving 185 hematologic cancer patients in China, was conducted between August 2024 and December 2024.
SeqFusionNet: A hybrid model for sequence-aware and globally integrated acoustic representation.
PLoS One
September 2025
College of Information Engineering, Sichuan Agricultural University, Ya'an, Sichuan Province, China.
Animals communicate information primarily via their calls, and directly using their vocalizations proves essential for executing species conservation and tracking biodiversity. Conventional visual approaches are frequently limited by distance and surroundings, while call-based monitoring concentrates solely on the animals themselves, proving more effective and straightforward than visual techniques. This paper introduces an animal sound classification model named SeqFusionNet, integrating the sequential encoding of Transformer with the global perception of MLP to achieve robust global feature extraction.
View Article and Find Full Text PDF