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Article Abstract
A DNA-silver cluster conjugate is a hierarchical chromophore with a partly reduced silver core embedded within the DNA nucleobases that are covalently linked by the phosphodiester backbone. Specific sites within a polymeric DNA can be targeted to spectrally tune the silver cluster. Here, the repeated (CA) strand is interrupted with a thymine, and the resulting (CA)-T-(CA) forms only Ag, a chromophore with both prompt (∼1 ns) green and sustained (∼10 μs) red luminescence. Thymine is an inert placeholder that can be removed, and the two fragments (CA) and (CA) also produce the same Ag adduct. In relation to (CA)T(CA), the (CA) + (CA) pair is distinguished because the red Ag luminescence is ∼6× lower, relaxes ∼30% faster, and is quenched ∼2× faster with O. These differences suggest that a specific break in the phosphodiester backbone can regulate how a contiguous vs broken scaffold wraps and better protects its cluster adduct.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10258842 | PMC |
| http://dx.doi.org/10.1021/acs.jpcc.3c01050 | DOI Listing |
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