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Multicomponent community-based obesity prevention interventions that engage multiple sectors have shown promise in preventing obesity in childhood; however, economic evaluations of such interventions are limited. This systematic review explores the methods used and summarizes current evidence of costs and cost-effectiveness of complex obesity prevention interventions. A systematic search was conducted using 12 academic databases and grey literature from 2006 to April 2022. Studies were included if they reported methods of costing and/or economic evaluation of multicomponent, multisectoral, and community-wide obesity prevention interventions. Results were reported narratively based on the Consolidated Health Economic Evaluation Reporting Standards. Seventeen studies were included, reporting costing or economic evaluation of 13 different interventions. Five interventions reported full economic evaluations, five interventions reported economic evaluation protocols, two interventions reported cost analysis, and one intervention reported a costing protocol. Five studies conducted cost-utility analysis, three of which were cost-effective. One study reported a cost-saving return-on-investment ratio. The economic evidence for complex obesity prevention interventions is limited and therefore inconclusive. Challenges include accurate tracking of costs for interventions with multiple actors, and the limited incorporation of broader benefits into economic evaluation. Further methodological development is needed to find appropriate pragmatic methods to evaluate complex obesity prevention interventions.
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http://dx.doi.org/10.1111/obr.13592 | DOI Listing |
JCO Clin Cancer Inform
August 2025
Telperian, Austin, TX.
Purpose: Lymphocytes play critical roles in cancer immunity and tumor surveillance. Radiation-induced lymphopenia (RIL) is a common side effect observed in patients with cancer undergoing chemoradiation therapy (CRT), leading to impaired immunity and worse clinical outcomes. Although proton beam therapy (PBT) has been suggested to reduce RIL risk compared with intensity-modulated radiation therapy (IMRT), this study used Bayesian counterfactual machine learning to identify distinct patient profiles and inform personalized radiation modality choice.
View Article and Find Full Text PDFCell Rep Med
July 2025
Sorbonne Université, INSERM U1269, Nutrition and obesities: systemic approach research group, Nutriomics, Paris F-75013, France. Electronic address:
Fibrosis in visceral white adipose tissue (vWAT) is closely associated with tissue dysfunction and systemic metabolic disturbances in obesity. Identifying pathways amenable to drug intervention to prevent fibrotic changes in vWAT is a critical step in addressing the array of metabolic complications associated with obesity. CD9 adipose progenitors (Progs) are key drivers of vWAT fibrosis.
View Article and Find Full Text PDFJAMA Netw Open
September 2025
Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Nutr Health
September 2025
Independent researcher, Rome, Italy.
Artificial intelligence (AI) is increasingly applied in nutrition science to support clinical decision-making, prevent diet-related diseases such as obesity and type 2 diabetes, and improve nutrition care in both preventive and therapeutic settings. By analyzing diverse datasets, AI systems can support highly individualized nutritional guidance. We focus on machine learning applications and image recognition tools for dietary assessment and meal planning, highlighting their potential to enhance patient engagement and adherence through mobile apps and real-time feedback.
View Article and Find Full Text PDFInvest Ophthalmol Vis Sci
September 2025
Eye Center, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang Provincial Key Laboratory of Ophthalmology. Zhejiang Provincial Clinical Research Center for Eye Diseases, Zhejiang Provincial Engineering Institute on Eye Diseases, Hangzhou, People's Republic of China.
Purpose: Evidence on the association between visceral obesity and diabetic retinopathy (DR) remains sparse and debatable. We aimed to use three novel indicators, body roundness index (BRI), lipid accumulation product (LAP), and visceral adiposity index (VAI), to investigate the longitudinal relationship between visceral obesity and DR, and explore the potential metabolic mechanisms.
Methods: In this prospective study based on the UK Biobank (UKB), 14,738 individuals with diabetes free of DR at baseline were included.