Article Synopsis
- Extracting biological information from awake and unrestrained mice is crucial for obtaining accurate data in research, as traditional methods can introduce confounding variables.
- Recent advancements in shortwave infrared (SWIR) fluorescent imaging allow researchers to visualize peripheral organs in mice that are free to move, enhancing the relevance of the data.
- The article explores the implications of SWIR imaging in neuroscience and other potential applications for studying live mice without the interference of anesthesia or restraint.
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Article Abstract
Extracting biological information from awake and unrestrained mice is imperative to basic and pre-clinical research. Accordingly, imaging methods which preclude invasiveness, anesthesia, and/or physical restraint enable more physiologically relevant biological data extraction by eliminating these extrinsic confounders. In this article, we discuss the recent development of shortwave infrared (SWIR) fluorescent imaging to visualize peripheral organs in freely-behaving mice, as well as propose potential applications of this imaging modality in the neurosciences.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10232761 | PMC |
| http://dx.doi.org/10.3389/fnins.2023.1135494 | DOI Listing |
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