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Background: Graft-tunnel mismatch (GTM) is a common problem in anterior cruciate ligament (ACL) reconstruction (ACLR) using bone-patellar tendon-bone (BPTB) grafts.
Hypothesis: Application of the "N+10 rule" in endoscopic ACLR with BPTB grafts will result in acceptable tibial tunnel length (TTL), minimizing GTM.
Study Design: Controlled laboratory study.
Methods: Endoscopic BPTB ACLR was conducted on the paired knees of 10 cadaveric specimens using 2 independent femoral tunnel drilling techniques-accessory anteromedial portal and flexible reamer. The graft bone blocks were trimmed to 10 × 20 mm, and the intertendinous distance (represented by "N") between the bone blocks was measured. The N+10 rule was used to set the angle of the ACL tibial tunnel guide to the appropriate number of degrees for drilling. The amount of excursion or recession of the tibial bone plug in relation to the anterior tibial cortical aperture was measured in both flexion and extension. A GTM threshold of ±7.5 mm was set based on prior studies.
Results: The mean BPTB ACL intertendinous distance was 47.5 ± 5.5 mm. The mean measured intra-articular distance was 27.2 ± 3 mm. Using the N+10 rule, the mean total (flexion plus extension) GTM was 4.3 ± 3.2 mm (GTM in flexion, 4.9 ± 3.6 mm; GTM in extension, 3.8 ± 3.5 mm). In 18 of 20 (90%) cadaveric knees, the mean total GTM fell within the ±7.5-mm threshold. When comparing the actual measured TTL to the calculated TTL, there was a mean difference of 5.4 ± 3.9 mm. When comparing femoral tunnel drilling techniques, the total GTM for the accessory anteromedial portal technique was 2.1 ± 3.7 mm, while the total GTM for the flexible reamer technique was 3.6 ± 5.4 mm ( = .5).
Conclusion: The N+10 rule resulted in an acceptable mean GTM in both flexion and extension. The mean difference between the measured versus calculated TTL using the N+10 rule was also acceptable.
Clinical Relevance: The N+10 rule is a simple and effective intraoperative strategy for achieving desired TTL regardless of patient-specific factors to avoid excessive GTM in endoscopic BPTB ACLR using independent femoral tunnel drilling.
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http://dx.doi.org/10.1177/23259671231168885 | DOI Listing |
Int J Med Inform
September 2025
Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address:
Background: Identifying patient-specific barriers to statin therapy, such as intolerance or deferral, from clinical notes is a major challenge for improving cardiovascular care. Automating this process could enable targeted interventions and improve clinical decision support (CDS).
Objective: To develop and evaluate a novel hybrid artificial intelligence (AI) framework for accurately and efficiently extracting information on statin therapy barriers from large volumes of clinical notes.
J Refract Surg
September 2025
Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Purpose: To evaluate axis-dependent visual and refractive outcomes of small incision lenticule extraction (SMILE) in patients with interocular astigmatic axis discordance.
Methods: Seventy-five patients (150 eyes) with interocular astigmatic axis discordance were included in the study. Based on interocular axis combinations, patients were stratified into three cohorts: with-the-rule (WTR)/against-the-rule (ATR) (n = 19), WTR/oblique astigmatism (OA) (n = 39), and ATR/OA (n = 17).
Alzheimers Dement
September 2025
Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Introduction: Antisocial behaviors occur in dementia, but the underlying neurocognitive mechanisms remain underexplored. We administered a decision-making task measuring patients' harm aversion by offering options to shock themselves or another person in exchange for money, hypothesizing that task performance would relate to antisocial behaviors and ventromedial/orbitofrontal cortex (vmPFC/OFC) atrophy.
Methods: Among 43 dementia patients (n = 23 behavioral variant frontotemporal dementia [bvFTD], n = 20 Alzheimer's disease [AD]), we used linear regressions to measure relationships between harm aversion and antisocial behavior, psychopathic personality traits, socioemotional functions, and vmPFC/OFC cortical thickness, controlling for age, sex, and cognitive dysfunction.
Inorg Chem
September 2025
Department of Chemistry and Chemical Engineering, Heze University, Heze, Shandong 274015, China.
Transition metal (TM)-doped silicon clusters represent critical model systems for understanding nanoscale hybridization and stability mechanisms. This study provides a comprehensive analysis of structural evolution, electronic properties, and thermodynamic stability in ruthenium-doped silicon clusters (RuSi̅, = 7-11) through integrated experimental and computational approaches. Anion photoelectron spectroscopy combined with density functional theory (DFT/B3LYP), coupled-cluster theory [CCSD(T)], and bonding analyses (AdNDP, NICS, ACID) reveals charge-state-dependent structural transitions, with full Ru encapsulation emerging at = 10 for anions and = 11 for neutrals.
View Article and Find Full Text PDFPhilos Trans R Soc Lond B Biol Sci
September 2025
Division of Evolution, Infection and Genomics, University of Manchester, Manchester M13 9PT, UK.
chronic lung infections pose serious challenges for phage therapy due to high between-patient strain diversity and rapid within-patient phenotypic and genetic diversification, necessitating simple predictors of efficacy to streamline phage cocktail design. We quantified bacteria-phage infection networks (BPINs) for six phages against 900 clones previously isolated from 10 bronchiectasis infections ( = 90 isolates per patient). BPIN structure varied extensively between patients.
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