Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Introduction And Objectives: Asthma is a chronic inflammatory disease of the airways. Asthma patients may experience potentially life-threatening episodic flare-ups, known as exacerbations, which may significantly contribute to the asthma burden. The and variants of the gene, which usually involve alpha-1 antitrypsin (AAT) deficiency, had previously been associated with asthma. The link between AAT deficiency and asthma might be represented by the elastase/antielastase imbalance. However, their role in asthma exacerbations remains unknown. Our objective was to assess whether genetic variants and reduced AAT protein levels are associated with asthma exacerbations.
Materials And Methods: In the discovery analysis, and variants and serum AAT levels were analyzed in 369 subjects from La Palma (Canary Islands, Spain). As replication, genomic data from two studies focused on 525 Spaniards and publicly available data from UK Biobank, FinnGen, and GWAS Catalog () were analyzed. The associations between and variants and AAT deficiency with asthma exacerbations were analyzed with logistic regression models, including age, sex, and genotype principal components as covariates.
Results: In the discovery, a significant association with asthma exacerbations was found for both (odds ratio [OR]=2.38, 95% confidence interval [CI]= 1.40-4.04, -value=0.001) and (OR=3.49, 95%CI=1.55-7.85, -value=0.003)Likewise, AAT deficiency was associated with a higher risk for asthma exacerbations (OR=5.18, 95%CI=1.58-16.92, -value=0.007) as well as AAT protein levels (OR= 0.72, 95%CI=0.57-0.91, -value=0.005). The association with exacerbations was replicated in samples from Spaniards with two generations of Canary Islander origin (OR=3.79, -value=0.028), and a significant association with asthma hospitalizations was found in the Finnish population (OR=1.12, -value=0.007).
Conclusions: AAT deficiency could be a potential therapeutic target for asthma exacerbations in specific populations.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.pulmoe.2023.05.002 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Steamed hay for the prevention of severe equine asthma exacerbations.
Equine Vet J
September 2025
Department of Clinical Sciences, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, Quebec, Canada.
Background: Steaming hay reduces respirable particles and is commonly used to feed horses with asthma. However, it showed inconsistent benefits in clinical studies.
Objectives: (1) To assess the effects of steamed hay on lung function and airway inflammation in horses with severe equine asthma (SEA) in remission; (2) To compare these effects with a dry hay diet.
Background: Current definitions of clinical remission (CR) use different tools and thresholds to define good asthma control. Their differential impact on CR rates in severe asthma is poorly understood.
Methods: Data from a real-world study in patients with SEA treated with benralizumab (imPROve Asthma, NCT04184284, total number of patients: 244 patients) were analyzed.
PVC Nanoplastics Exposure Exacerbates Asthma through R-Loop Accumulation and Subsequent STING Activation in Macrophages.
Adv Sci (Weinh)
September 2025
Postgraduate training base Alliance of Wenzhou Medical University (Zhejiang Cancer Hospital), Hangzhou, 310022, China.
Asthma is a chronic inflammatory respiratory disease influenced by genetic and environmental factors. Emerging evidence suggests that microplastics and nanoplastics (NPs) pose significant health risks. When inhaled, these tiny particles can accumulate in the lungs, triggering inflammation, oxidative stress, and other disruptions in pulmonary function.
View Article and Find Full Text PDFClinical, functional, and laboratory course of children and adolescents with severe asthma after discontinuation of biologics.
Front Allergy
August 2025
Unit of Pediatric Allergy and Respiratory Medicine, Women's and Children's Health Department, University Hospital of Padova, Padova, Italy.
Background: Although the benefits of biologics in severe asthma are well established, the optimal strategy to discontinue therapy remains controversial.
Aim: to evaluate clinical, functional, and laboratory course of children and adolescents with severe asthma after biological therapy withdrawal due to sustained good control. Secondary aim was to identify clinical or inflammatory markers predictive of asthma control after discontinuation.
Asthma care bundle and pathway to improve asthma management in a community paediatric inpatient unit, a quality improvement initiative.
Paediatr Child Health
August 2025
Department of Pediatrics & Island Medical Program, Faculty of Medicine, University of British Columbia, Victoria, British Columbia, Canada.
Background: Asthma is the most common chronic paediatric condition and a frequent cause of emergency department visits and hospitalizations.
Objectives: The project objective was to decrease inpatient length of stay (LOS) for asthma exacerbations between May 2021 and 2022.
Methods: The Institute for Healthcare Improvement Model for improvement was employed to study if systemic changes to asthma management could reduce hospital LOS.