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http://dx.doi.org/10.23736/S2724-6051.23.05354-5 | DOI Listing |
J Helminthol
September 2025
Department of Zoology, Faculty of Science, https://ror.org/00jxshx33South Valley University, Qena, Qena Governorate, 83523, Egypt.
The taxonomic status of Oshmarin, Mamaev & Parukhin, 1961 () and Manter, 1963 is controversial due to overlap/confusion in distinctive diagnostic characteristics for each genus and morphological/allometric ambiguity among some of their representatives and/or within records of the same species. To address these in-depth, morphological descriptions, molecular characterizations, and species delimitation analyses were conducted using a combination of comparative morphology, molecular phylogeny, multivariate analyses, and host-parasite data. Following a comprehensive review, a refined restricted concept of and is proposed.
View Article and Find Full Text PDFAnn Intensive Care
September 2025
School of Computer Science and Technology, Hangzhou Dianzi University, No. 1158, No. 2 Road, Xiasha Higher Education Zone, Hangzhou, 310018, Zhejiang Province, China.
J Transl Med
September 2025
Department of Veterinary Medical Sciences, University of Bologna, Ozzano dell'Emilia, Bologna, BO, Italy.
Endogenous transposable elements (TEs) are receiving increasing attention as potential targets to develop novel immunostimulatory strategies against cancer. Indeed, the defective epigenetic suppression of TEs in malignant cells offers a therapeutic window to enable their re-activation with at least some degree of selectivity. In line with this notion, multiple clinically employed epigenetic modifiers such as DNA-demethylating agents have been shown to promote the re-expression of TEs in preclinical tumour models, hence driving powerful inflammatory responses that enables increased sensitivity of immunitary immune cells to immunotherapy with immune checkpoint inhibitors (ICIs).
View Article and Find Full Text PDFJ Clin Invest
September 2025
The search for transformative medicines has continuously uncovered select diseases associated with the disruption of the endocannabinoid (eCB) signaling system in the brain and emphasized the therapeutic value of small molecules that rescue this signaling system. In this issue of JCI, Wang et al. report that genetic disruption of PPP2R1A function in mouse forebrain, a preclinical mouse model of neurodevelopmental disorders, resulted in pronounced impairment of eCB signaling.
View Article and Find Full Text PDFUpdates Surg
September 2025
General Medicine, Andhra Medical College, Visakhapatnam, Andhra Pradesh, 530002, India.