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Purpose: Asynchronous home-based cardiac rehabilitation (HBCR) is a viable alternative to center-based cardiac rehabilitation (CBCR). However, to achieve significant functional improvement, a high level of adherence and activity must be achieved. The effectiveness of HBCR among patients who actively avoid CBCR has not been effectively investigated. This study aimed to investigate the effectiveness of the HBCR program among patients unwilling to participate in CBCR.
Methods: A randomized prospective study enrolled 45 participants to a 6-mo HBCR program and the remaining 24 were allocated to regular care. Both groups were digitally monitored for physical activity (PA) and self-reported outcomes. Change in peak oxygen uptake (VO 2peak ), the primary study outcome, was measured by the cardiopulmonary exercise test, immediately before program start and 4 mo thereafter.
Results: The study included 69 patients, 81% men, aged 55.9 ±12 yr, enrolled in a 6-mo HBCR program to follow a myocardial infarction (25.4%) or coronary interventions (41.3%), heart failure hospitalization (29%), or heart transplantation (10%). Weekly aerobic exercise totaled a median of 193.2 (110.2-251.5) min (129% of set exercise goal), of which 112 (70-150) min was in the heart rate zone recommended by the exercise physiologist.After 4 mo, VO 2peak improved by 10.2% in the intervention group versus -2.7% in the control group (+2.46 ± 2.67 vs -0.72 ± 3.02 mL/kg/min; P < .001).
Conclusion: The monthly PA of patients in the HBCR versus conventional CBCR group were well within guideline recommendations, showing a significant improvement in cardiorespiratory fitness. Risk level, age, and lack of motivation at the beginning of the program did not prevent achieving goals and maintaining adherence.
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http://dx.doi.org/10.1097/HCR.0000000000000796 | DOI Listing |
Case Rep Psychiatry
August 2025
Department of Psychiatry and Behavioral Medicine, Marshall University Joan C. Edwards School of Medicine, Huntington, West Virginia, USA.
Delayed posthypoxic leukoencephalopathy (DPHL) is a rare diagnosis that may present similarly to other more common neurological conditions, such as catatonia. While often seen with carbon-monoxide poisoning, it can also be due to anoxia due to other causes, such as drug overdose or cardiac arrest. Due to the delayed nature of its symptoms and overlap with other conditions, it can be initially misdiagnosed.
View Article and Find Full Text PDFFront Cardiovasc Med
August 2025
Department of Rehabilitation Medicine, School of Acupuncture-Moxibustion and Tuina and School of Health Preservation and Rehabilitation, Nanjing University of Chinese Medicine, Nanjing, China.
Background: Anthracycline-based chemotherapy is a highly effective treatment for numerous cancers, yet its clinical use is severely limited by cumulative, dose-dependent cardiotoxicity. MicroRNAs (miRNAs), as key post-transcriptional regulators of gene expression, play a pivotal role in the pathophysiology of cardiovascular disease, but their specific functions in anthracycline-induced cardiotoxicity (AIC) require systematic elucidation.
Purpose: This review aims to systematically summarize current research on the key miRNAs, their molecular targets, and associated signaling pathways that regulate AIC, while also exploring their potential as biomarkers for early diagnosis and as therapeutic targets for intervention.
Telemed Rep
July 2025
Department of Health Science and Technology, Aalborg University, Aalborg, Denmark.
Introduction: Cardiovascular disease is a leading global cause of death, with coronary artery disease often requiring coronary artery bypass grafting (CABG). Inadequate rehabilitation increases health risks and costs, and low adherence to center-based rehabilitation has prompted interest in telerehabilitation. Despite technological advances, the global implementation of telerehabilitation for CABG patients remains underexplored.
View Article and Find Full Text PDFJ Educ Health Promot
July 2025
Faculty of Health, York University, Toronto.
Background: Despite the benefits of cardiac rehabilitation (CR), women are under-represented, especially in lower-income settings. Technology may be leveraged to tailor CR to better engage women, but this has never been tested in a middle-income country. This study assessed the implementability, usability, engagement, and acceptability of Technology-bAsed Cardiac rehabilitation Therapy (TaCT) in women with cardiovascular disease (CVD) in a middle-income country.
View Article and Find Full Text PDFJ Educ Health Promot
July 2025
Shahid Ashrafi Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
Background: Acute myocardial infarction (MI), as a serious and fatal heart disease and an important medical emergency, imposes the large financial burden on the health and treatment systems of countries and the family economy. In the meantime, starting rehabilitation programs after acute myocardial infarction as soon as possible can minimize the unfortunate and irreparable side effects. Therefore, the present study was conducted with the aim of evaluating the effectiveness of an educational program on health index in the MI patients hospitalized in CCU ward.
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