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Eukaryotic genomes are pervasively translated, but the properties of translated sequences outside of canonical genes are poorly understood. A new study in Cell Systems reveals a large translatome that is not under significant evolutionary constraint but is still an active part of diverse cellular systems.
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http://dx.doi.org/10.1016/j.cels.2023.04.004 | DOI Listing |
Cereb Cortex
August 2025
Department of Psychology, University of Lübeck, Ratzeburger Allee 160, Lübeck 23562, Germany.
The human auditory system must distinguish relevant sounds from noise. Severe hearing loss can be treated with cochlear implants (CIs), but how the brain adapts to electrical hearing remains unclear. This study examined adaptation to unilateral CI use in the first and seventh months after CI activation using speech comprehension measures and electroencephalography recordings, both during passive listening and an active spatial listening task.
View Article and Find Full Text PDFPhys Eng Sci Med
September 2025
Department of Physics, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok, 16424, Indonesia.
This study introduces a novel optimization framework for cranial three-dimensional rotational angiography (3DRA), combining the development of a brain equivalent in-house phantom with Figure of Merit (FOM) a quantitative evaluation method. The technical contribution involves the development of an in-house phantom constructed using iodine-infused epoxy and lycal resins, validated against clinical Hounsfield Units (HU). A customized head phantom was developed to simulate brain tissue and cranial vasculature for 3DRA optimization.
View Article and Find Full Text PDFBrain Behav
September 2025
Radiology Department, Yantaishan Hospital, Yantai, Shandong, China.
Objective: To investigate the characteristics of brain structures in patients with noise-induced hearing loss (NIHL) using source-based morphometry (SBM) and to evaluate the correlation between abnormal brain regions and clinical data.
Methods: High-resolution 3D T1 structural images were acquired from 81 patients with NIHL and 74 age- and education level-matched healthy controls (HCs). The clinical data of all subjects were collected, including noise exposure time, monaural hearing threshold weighted values (MTWVs), Mini-Mental State Examination (MMSE), and Hamilton Anxiety Scale (HAMA) scores.
Hum Brain Mapp
September 2025
Tri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, and Emory University, Atlanta, Georgia, USA.
Investigating neuroimaging data to identify brain-based markers of mental illnesses has gained significant attention. Nevertheless, these endeavors encounter challenges arising from a reliance on symptoms and self-report assessments in making an initial diagnosis. The absence of biological data to delineate nosological categories hinders the provision of additional neurobiological insights into these disorders.
View Article and Find Full Text PDFACS Electrochem
September 2025
Department of Chemistry and Chemical Engineering, Chalmers University of Technology, Kemigården 4, Gothenburg 412 96, Sweden.
Carbon fiber nanotip electrodes (CFNEs) are crucial for electrochemical recordings of neurotransmission release in confined spaces, such as synapses and intracellular measurements. However, fabricating CFNEs with small surface area to minimize noise remains challenging due to inconsistent tip size control, low reproducibility, and low fabrication success rate. Here, we present a reliable, user-friendly method with high reproducibility and success rate for precise CFNE fabrication using microscopy-guided electrochemical etching of cylindrical carbon fiber microelectrodes in a potassium hydroxide droplet.
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