Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
This in vivo study reports the influence of minocycline-HCl administration on extra-skeletal bone generation in a Guided Bone Augmentation model, utilizing titanium caps placed on the intact as well as perforated calvaria of rats. The test group was administered 0.5 mg/mL minocycline-HCl with the drinking water, and the amount of bone tissue in the caps was quantified at three time points (4, 8 and 16 weeks). A continuously increased tissue fill was observed in all groups over time. The administration of minocycline-HCl as well as perforation of the calvaria increased this effect, especially with regard to mineralization. The strongest tissue augmentation, with 1.8 times that of the untreated control group, and, at the same time, the most mineralized tissue (2.3× over untreated control), was produced in the combination of both treatments, indicating that systemic administration of minocycline-HCl has an accelerating and enhancing effect on vertical bone augmentation.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136768 | PMC |
| http://dx.doi.org/10.3390/dj11040092 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Diffusion model-empowered patella shape analysis predicts knee osteoarthritis outcomes.
Osteoarthr Cartil Open
December 2025
Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong Special Administrative Region of China.
Objective: We developed and validated an artificial intelligence pipeline that leverages diffusion models to enhance prognostic assessment of knee osteoarthritis (OA) by analyzing longitudinal changes in patella shape on lateral knee radiographs.
Method: In this retrospective study of 2,913 participants from the Multicenter Osteoarthritis Study, left-knee weight-bearing lateral radiographs obtained at baseline and 60 months were analyzed. Our pipeline commences with an automatic segmentation for patella shapes, followed by a diffusion model to predict patella shape trajectories over 60 months.
Responsiveness of the PROMIS-10 global compared to the neck disability index in patients undergoing 1 and 2 level anterior cervical discectomy and fusion.
N Am Spine Soc J
September 2025
Orthopedic Research Department, 31 Seymour St. Hartford HealthCare Bone and Joint Institute, Hartford, CT, 06106 United States.
Background: The reliance on patient reported outcomes (PROs) has substantially increased not only to augment current metrics of clinical success, but to capture the patient's perspective on the benefit of their treatment. As more PROs become utilized, the time and cost of longitudinal data collection and survey fatigue must be tempered with the benefit of the data collected. Therefore, this study sought to assess the responsiveness of the Neck Disability Index (NDI) compared to the PROMIS-10 Global Health Survey physical function T-score (PFT) and mental health T-score (MHT).
View Article and Find Full Text PDFFunctional Mandibular Reconstruction With Integrated Nerve Repair: A Pathway to Dental Implant Rehabilitation.
Cureus
August 2025
Dental and Oral Medical Center, Kurume University School of Medicine, Kurume, JPN.
Functional reconstruction of large mandibular defects, especially in young patients, presents a significant clinical challenge. The ideal approach should not only restore skeletal contour but also address nerve deficits and facilitate final occlusal rehabilitation, all while minimizing morbidity. This report describes a comprehensive, multi-staged strategy for such a case.
View Article and Find Full Text PDF3D-printed copper-containing tailored titanium alloys with corrosion resistance, biocompatibility, and anti-inflammatory properties for enhanced guided bone regeneration.
Front Bioeng Biotechnol
August 2025
Institute of Stomatology and Laboratory of Oral Tissue Engineering, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China.
Introduction: Guided bone regeneration (GBR) serves as a critical technique in dental implantology, relying heavily on barrier membranes for successful alveolar bone augmentation. Titanium mesh, widely utilized in GBR procedures, faces a high exposure rate that leads to infections and compromised clinical outcomes. While 3D-printed personalized meshes have reduced exposure rates, infection risks persist, necessitating the development of bioactive solutions.
View Article and Find Full Text PDFDistinct effects of adjuvants on B cell responses to protein or polysaccharide antigens contained in glycoconjugate vaccines.
Front Immunol
September 2025
Bacterial Scientific Area, GSK Vaccine, Siena, Italy.
Background: Protein-polysaccharide conjugate vaccines rely on the induction of T-cell-dependent responses that support germinal center (GC) reactions to potentiate the expansion of antigen-specific memory B-cell (MBC) populations and high-avidity antibody responses. The effects of adjuvants on B-cell and antibody responses are well described for protein antigens but remain largely unexplored for conjugated polysaccharidic antigens.
Methods: We assessed the effects of five adjuvants present in licensed vaccines (AS01, AS03, AS04, and aluminum hydroxide [Alum]) or under clinical evaluation (AS37) on the magnitude and quality of antigen-specific antibody responses and local/systemic B-cell responses.