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The aim of this study was to observe the 1-year clinical outcomes of people with type 1 diabetes who switched from multiple daily injection + blood glucose meter to an advanced hybrid closed-loop (AHCL) system (Medtronic MiniMed™ 780G system [MM 780G]). In addition, the effect of changing at month 6 to a calibration-free sensor (Guardian™ 4 Sensor [G4S]) was evaluated. Eighteen participants (10 men, age 40.9 ± 7.6 years) completed 1 year of MM 780G use. Time in range (TIR; 70-180 mg/dL) remained stable and ranged from 83.2% in month 9 to 84.8% in month 3. There was no difference between TIR at 3 months before switching versus 3 months after switching to G4S ( = 0.614). AHCL system in adults significantly improves glycemic outcomes. This improved glycemic control was maintained over the 12 months. Switching to a calibration-free sensor (G4S) did not affect outcomes but required less patient involvement.
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http://dx.doi.org/10.1089/dia.2023.0059 | DOI Listing |
We propose an integrated optoelectronic platform based on paired semiconducting nanostructures, which features a photonic-electronic co-design where the semiconducting nanostructures serve dual purposes: enabling refractive index (RI)-sensitive optical resonance while facilitating efficient near-field optoelectronic conversion through photoconducting effect. Importantly, unlike conventional single-sensor designs, our on-chip approach implements multi-dimensional extraction through a response matrix for RI-resolved measurements. By maximizing the response matrix determinant and optoelectronic RI sensitivity, we achieve an RI detection limit of 1 × 10 RIU/Hz.
View Article and Find Full Text PDFThis manuscript presents a quantum-cascade-laser-absorption-spectroscopy (QCLAS) diagnostic for measuring the rotational and vibrational temperatures, partial pressure, and velocity of nitric oxide (NO) in hypersonic flows at rates up to 500 kHz. Two fiber-coupled distributed-feedback QCLs and a 3D-printed optical probe were used to measure the aforementioned properties via a single retroreflected beam and a single detector. This approach was taken to minimize spatial averaging and sensor complexity while still providing a self-referenced calibration-free velocity measurement.
View Article and Find Full Text PDFNatural gas (NG) is a potential substitute for diesel in engine applications because of its potential to reduce greenhouse gas and toxicant emissions. To maximize the benefits of NG, robust diagnostic methods are required to quantify concentration of unburned methane in the exhaust stream, without requiring frequent sensor recalibration. A wavelength modulation spectroscopy sensor has been developed to measure slip from NG engines.
View Article and Find Full Text PDFTalanta
July 2025
School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275, People's Republic of China; Key Laboratory for Polymeric Composite & Functional Materials of Ministry of Education, School of Chemistry, Sun Yat-sen University, Guangzhou, 510275, People's Republic of China.
A major obstacle in the development of solid contact ion-selective electrodes (SC-ISEs) is the frequent calibration procedures due to the low reproducibility of standard potential(E) and the unstable signals. To address these challenges, we developed an all-solid state miniature sodium ion-selective electrode (Na-ISE) based on acid-doped poly(3,4-ethylenedioxythiophene)-polystyrene sulphonate (PEDOT: PSS) as the solid contact layer, in combination with an external polarization technique. Acid doping minimized the Coulomb interaction between PEDOT and PSS, inducing significant phase separation and conformational re-aggregation of PEDOT chains, thus creating more contact points to facilitate charge transport and ion-to-electron transduction.
View Article and Find Full Text PDFTalanta
July 2025
Saint Petersburg State University 7/9, Universitetskaya nab., Saint Petersburg, Russia.
In this study, we present a color scale-based approach for the rapid and sensitive visual detection of lead(II) in human urine using a polymer-based optical sensor. The optimized optode membrane demonstrates a detection limit of 6 ± 4 μg × L, making it suitable for both point-of-care diagnostics and environmental applications. Response characteristics, including median signal, dynamic range, and response time, were evaluated, and the influence of membrane composition, both qualitative and quantitative, on optical performance was systematically investigated.
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