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Article Abstract
The first diastereoselective synthesis of (-)-1--lentiginosine from a common chiral -epoxyamide derived from 2-pyridincarbaldehyde is reported. This methodology involves a sequential oxirane ring opening and intramolecular 5-- cyclization of tosylate -epoxyalcohol to afford a diastereomeric mixture of indolizinium salts in a one-pot fashion, followed by regio- and diastereospecific pyridinium ring reduction.
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| http://dx.doi.org/10.3390/molecules28093719 | DOI Listing |
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