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This study compared the relative performance of alternative frequency weightings of hand-transmitted vibration (HTV) to predict the extent of cold-induced vasoconstriction in the digital arteries of HTV workers. The cold response of digital arteries was related to measures of daily vibration exposure expressed in terms of r.m.s. acceleration magnitude normalised to an 8-h day, frequency weighted according to either the frequency weighting W defined in international standard ISO 5349-1:2001 (A(8) in ms r.m.s.) or the hand-arm vascular frequency weighting W proposed in the ISO Technical Report 18570:2007 (A(8) in ms r.m.s.). The measure of daily vibration exposure constructed with the frequency weighting W (A(8)) was a better predictor of the cold response of the digital arteries in the HTV workers than the metric derived from the conventional ISO frequency weighting W (A(8)). This finding suggests that a measure of daily vibration exposure constructed with the vascular weighting W, which gives more weight to intermediate- and high-frequency vibration (31.5-250 Hz), performed better for the prediction of cold induced digital arterial hyperresponsiveness than that obtained with the frequency weighting W recommended in ISO 5349-1 which gives more importance to lower frequency vibration (≤16 Hz).
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http://dx.doi.org/10.2486/indhealth.2023-0023 | DOI Listing |
JMIR Public Health Surveill
September 2025
Earth Observation Centre (EOC), Institute of Climate Change, Universiti Kebangsaan Malaysia, Bangi, Selangor, Malaysia.
Background: Neighborhoods resulting from rapid urbanization processes are often saturated with eateries for local communities, potentially increasing exposure to unhealthy foods and creating diabetogenic residential habitats.
Objective: We examined the association between proximity of commercial food outlets to local neighborhood residences and type 2 diabetes (T2D) cases to explore how local T2D rates vary by location and provide policy-driven metrics to monitor food outlet density as a potential control for high local T2D rates.
Methods: This cross-sectional ecological study included 11,354 patients with active T2D aged ≥20 years geocoded using approximate neighborhood residence aggregated to area-level rates and counts by subdistricts (mukims) in Penang, northern Malaysia.
JCO Clin Cancer Inform
August 2025
Telperian, Austin, TX.
Purpose: Lymphocytes play critical roles in cancer immunity and tumor surveillance. Radiation-induced lymphopenia (RIL) is a common side effect observed in patients with cancer undergoing chemoradiation therapy (CRT), leading to impaired immunity and worse clinical outcomes. Although proton beam therapy (PBT) has been suggested to reduce RIL risk compared with intensity-modulated radiation therapy (IMRT), this study used Bayesian counterfactual machine learning to identify distinct patient profiles and inform personalized radiation modality choice.
View Article and Find Full Text PDFPLoS Comput Biol
September 2025
Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, United States of America.
Compartmental infectious disease models are used to calculate disease transmission, estimate underlying rates, forecast future burden, and compare benefits across intervention scenarios. These models aggregate individuals into compartments, often stratified by characteristics to represent groups that might be intervention targets or otherwise of particular concern. Ideally, model calculation could occur at the most demanding resolution for the overall analysis, but this may be infeasible due to availability of computational resources or empirical data.
View Article and Find Full Text PDFPLoS One
September 2025
Department of Population Health Sciences, University of Utah, Salt Lake City, Utah, United States of America.
While the COVID-19 pandemic has significantly impacted mental health, limited information exists on the relationship between COVID-19 infection and mental health disorders in children and adolescents. This study explored the association between COVID-19 infection, infection severity, and the risk of depression and anxiety among school-aged youth. Data from the 2019-2021 Utah All Payers Claims Database (APCD) was used to identify children and adolescents (aged 6-15 years in 2019) covered by private insurance or Medicaid.
View Article and Find Full Text PDFBackground: Overweight and obesity are major concerns among people living with HIV (PLWH), particularly those on integrase inhibitors, as they elevate the risk of cardiovascular diseases. However, longitudinal data on the burden and risk factors for overweight/obesity in sub-Saharan Africa (SSA) remain limited. This study aimed to estimate the incidence and identify factors associated with overweight and obesity among PLWH who switched to a dolutegravir (DTG)-based ART regimen at Livingstone University Teaching Hospital.
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