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Article Abstract
Understanding pattern formation driven by cell-cell interactions has been a significant theme in cellular biology for many years. In particular, due to their implications within many biological contexts, lateral-inhibition mechanisms present in the Notch-Delta signalling pathway led to an extensive discussion between biologists and mathematicians. Deterministic and stochastic models have been developed as a consequence of this discussion, some of which address long-range signalling by considering cell protrusions reaching non-neighbouring cells. The dynamics of such signalling systems reveal intricate properties of the coupling terms involved in these models. In this work, we investigate the advantages and drawbacks of a single-parameter long-range signalling model across diverse scenarios. By employing linear and multi-scale analyses, we discover that pattern selection is not only partially explained but also depends on nonlinear effects that extend beyond the scope of these analytical techniques.
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| http://dx.doi.org/10.1016/j.mbs.2023.109012 | DOI Listing |
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Article Synopsis
- Mammalian Notch signaling is initiated when Delta or Jagged proteins bind to the Notch receptor, leading to the release of the Notch intracellular domain (NICD) that influences gene expression in the nucleus.
- Researchers used fluorescent tagging to observe the interactions between Notch and Delta in real-time as they interacted between sender and receiver cells after contact.
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