Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Previous studies reported that patients with asthma showed higher levels of interleukin (IL)-33 in peripheral blood, compared to healthy control (HCs). However, we also noticed that there were no significant differences of IL-33 levels between controls and asthma patients in a recent study. We aim to conduct this meta-analysis and evaluate the feasibility of IL-33 in peripheral blood that may act as a promising biomarker in asthma.
Methods: Articles published before December 2022 were searched in these databases (PubMed, Web of Science, EMBASE, and Google Scholar). We used STATA 12.0 software to compute the results.
Results: The study showed that asthmatics showed higher IL-33 level in serum and plasma, compared to HCs (serum: standard mean difference [SMD] 2.06, 95% confidence interval [CI] 1.12-3.00, I = 98.4%, p < .001; plasma: SMD 3.67, 95% CI 2.32-5.03, I = 86.0%, p < .001). Subgroup analysis indicated that asthma adults showed higher IL-33 level in serum, compared to HCs, whereas no significant difference in IL-33 level in serum was showed between asthma children and HCs (adults: SMD 2.17, 95% CI 1.09-3.25; children: SMD 1.81, 95% CI -0.11 to 3.74). The study indicated that moderate and severe asthmatics showed higher IL-33 level in serum, compared to mild asthmatics (SMD 0.78, 95% CI 0.41-1.16, I = 66.2%, p = .011).
Conclusions: In conclusion, the main findings of present meta-analysis suggested that there was a significant correlation between IL-33 levels and the severity of asthma. Therefore, IL-33 levels of either serum or plasma may be regarded as a useful biomarker of asthma or the degree of disease.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10116908 | PMC |
| http://dx.doi.org/10.1002/iid3.842 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Analysis of the Innate Immune Response to Febrile UTI in Infants: Evidence of an Acute Cytokine Storm.
Pediatr Infect Dis J
August 2025
From the Division of Microbiology, Immunology and Glycobiology, Department of Laboratory Medicine, Lund University.
Background: Infections trigger complex immune responses, with conserved as well as disease-specific characteristics.
Methods: Proteomic screening technology and gene expression analysis were used here to define the immune response in infants, with their first episode of febrile urinary tract infection. Urine and peripheral blood samples were obtained at enrollment and at follow-up, after 6 months.
CREB regulates Foxp3ST-2 T with enhanced IL-10 production.
Front Immunol
August 2025
Department of Pediatrics, Rheinisch-Westfälische Technische Hochschule Aachen University Hospital, Aachen, Germany.
Introduction: Regulatory T-cells (T) are characterized by the expression of Foxp3, a master regulator involved in the development and function of T. Foxp3 expression is dependent on activity of the Treg specific demethylated site (TSDR), which contains a CREB binding site. We aimed to find out how Foxp3 specific CREB deletion affects Treg expression and function.
View Article and Find Full Text PDFEx Vivo Cytokine Profiling of Cryptococcus neoformans Strains Suggests Strain-Specific Immune Modulation: A Cross-Sectional Study.
Cureus
July 2025
Department of Microbiology and Parasitology, Mbarara University of Science and Technology, Mbarara, UGA.
Cryptococcal meningitis (CM) remains a major cause of mortality among people living with human immunodeficiency virus (HIV), especially in sub-Saharan Africa. The interplay between fungal genotype and host immune response is critical in determining disease outcome. We conducted ex vivo cytokine profiling using peripheral blood from HIV-positive and HIV-negative adults stimulated with heat-inactivated whole-cell antigens from two strains: the reference strain H99 and the genetically distinct UgCl377 clinical strain.
View Article and Find Full Text PDFDecreased IL-33 in the brain following repetitive mild traumatic brain injury contributes to cognitive impairment by inhibiting microglial phagocytosis.
Mil Med Res
August 2025
Department of Geriatrics, Tianjin Medical University General Hospital, Tianjin, 300052, China.
Background: Repetitive mild traumatic brain injury (rmTBI) is a significant risk factor for neurodegeneration, characterized by pathological protein deposition and persistent neuroinflammation. Research has observed increased interleukin-33 (IL-33) levels in the peripheral blood of patients with rmTBI, suggesting IL-33 may participate in regulating the pathological development of rmTBI. The study aims to elucidate the impact and mechanism of IL-33 in the progression of neuropathology following rmTBI, and to explore its potential as a therapeutic target to improve the neurological outcome.
View Article and Find Full Text PDFIntegrative analysis reveals novel inflammatory and metabolic pathways in glioblastoma development: A large-scale mediation Mendelian randomization study.
Medicine (Baltimore)
August 2025
Department of Neurology, The First Hospital of China Medical University, Shenyang, China.
Glioblastoma (GBM) is one of the most lethal central nervous system malignancies, characterized by complex inflammatory responses and metabolic reprogramming. However, the causal relationships between inflammatory factors, metabolites, and GBM risk remain largely unclear. We conducted a 3-stage Mendelian randomization analysis using data from the FinnGen biobank (341 GBM cases and 314,193 controls) and genome-wide association studies of 91 inflammatory factors and 1400 metabolites.
View Article and Find Full Text PDF