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Article Abstract
Unlabelled: As a functional component of erythrocyte hemoglobin, iron is essential for oxygen delivery to all tissues in the body. The liver-derived peptide hepcidin is the master regulator of iron homeostasis. During anemia, the erythroid hormone erythroferrone regulates hepcidin synthesis to ensure adequate supply of iron to the bone marrow for red blood cells production. However, mounting evidence suggested that another factor may exert a similar function. We identified the hepatokine FGL1 as a previously undescribed suppressor of hepcidin that is induced in the liver in response to hypoxia during the recovery from anemia and in thalassemic mice. We demonstrated that FGL1 is a potent suppressor of hepcidin and . Deletion of in mice results in a blunted repression of hepcidin after bleeding. FGL1 exerts its activity by direct binding to BMP6, thereby inhibiting the canonical BMP-SMAD signaling cascade that controls hepcidin transcription.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104156 | PMC |
| http://dx.doi.org/10.1101/2023.04.06.535920 | DOI Listing |
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Article Synopsis
- The study investigates serum levels of Fibrinogen-like protein (FGL)-1 in bariatric patients undergoing laparoscopic sleeve gastrectomy (LSG) to understand its role in liver health.
- Ninety-two participants were analyzed before and six months after surgery, revealing that obese patients had significantly higher FGL-1 levels compared to those with normal weight, which decreased post-surgery.
- Results indicated that lower FGL-1 levels post-surgery correlated with improvements in liver enzymes and uric acid levels, suggesting that FGL-1 could serve as a predictor for liver fibrosis recovery after weight loss surgery.