Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Bee propolis has been used in alternative medicine to treat various diseases. Due to its limited water solubility, it is often used in combination with alcohol solvents, causing skin irritation and immune response. To solve this, the new drug delivery system, based on the lipid nanodiscs of 1,2-dimyristoyl--glycero-3-phosphochline (DMPC) and poly(styrene--maleic acid) (PSMA), were created in an aqueous media. At the excess polymer concentrations, the PSMA/DMPC complexation produced the very fine nanoparticles (18 nm). With the increased molar ratio of styrene to maleic acid (St/MA) in the copolymer structure, the lipid nanodisc showed the improved encapsulation efficiency (EE%), comparing to their corresponding aqueous formulations. The maximum value had reached to around 20% when using the 2:1 PSMA precursor. Based on the cytotoxicity test, these nanoparticles were considered to be non-toxic over the low dose administration region (<78 µg/mL). Instead, they possessed the ability to promote the Vero cell growth. The new PSMA/DMPC nanovesicles could thus be used to improve aqueous solubility and therapeutic effects of poorly water-soluble drugs, thus extending their use in modern therapies.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/21691401.2023.2198570 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A thermochromic tissue-mimicking phantom for catheter-based radiofrequency ablation of heterogenous lesions.
Med Phys
September 2025
School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, P.R. China.
Background: In catheter-based radiofrequency ablation (RFA), energy is delivered to heterogeneous thin-walled tissues to induce therapeutic heating. Variations in electrical and mechanical properties of tissue contents have a great effect on outcomes.
Purpose: The objective of this study is to develop models that replicate tissue heterogeneity and visualize ablation zones for effective evaluation and optimization.
Novel development of lipid-based formulations: Improved wettability and homogeneous API solid dispersion visualised via near-infrared hyperspectral imaging.
Eur J Pharm Biopharm
September 2025
Research Center Pharmaceutical Engineering GmbH, Inffeldgasse 13, 8010 Graz, Austria; University of Graz, Institute of Pharmaceutical Sciences, Department of Pharmaceutical, Technology and Biopharmacy, Graz, Austria. Electronic address:
Lipid-based formulations have been successfully applied to improve the aqueous solubility of active pharmaceutical ingredients (APIs), however, with the bottleneck of limited wettability of the system. In this study, a lipid-based system was developed using polyglycerol ester of fatty acids (PGFA) as the main component and hexaglycerol (PG6) as a wetting agent. Felodipine, a BCS class II compound was selected as a model API.
View Article and Find Full Text PDFSolvent-Directed Self-Assembly of Sorafenib into Spherical Particles for Enhanced Anticancer Efficacy.
Nano Lett
September 2025
KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul 02841, Republic of Korea.
Sorafenib, a clinically approved multityrosine kinase inhibitor, exhibits poor aqueous solubility, which limits its bioavailability and therapeutic efficacy. In this study, we introduce a solvent-directed self-assembly strategy to modulate the nanostructure of sorafenib without the use of external carriers or complex formulation techniques. In pure water, sorafenib forms large lamellar aggregates, whereas in 30% methanol-water mixtures, it self-assembles into uniform spherical particles approximately 450 nm in diameter.
View Article and Find Full Text PDFMolecular properties and intramolecular interactions of peptide-conjugated phosphorodiamidate morpholino oligonucleotides.
Mol Ther Nucleic Acids
September 2025
Department of Chemistry, University of Massachusetts, Lowell, MA 01854, USA.
We combined circular dichroism (CD) and viscosity measurements with molecular dynamics (MD) simulations and classification and regression approaches to machine learning to characterize solution structures of 22-mer, 25-mer, and 30-mer peptide- (-GlyArg6) conjugated phosphorodiamidate morpholino oligonucleotides (PPMOs). PPMO molecules form non-canonical folded structures with 1.4- to 1.
View Article and Find Full Text PDFOptimization of Levomilnacipran Loaded Nanostructured Lipid Carrier Using Response Surface Methodology.
Pharm Nanotechnol
August 2025
Department of Pharmaceutics, SRM College of Pharmacy, Kattankulathur, India.
Aim: The study employed Response Surface Methodology (RSM) with a Central Composite Rotatable Design (CCRD) model to optimise the formulations of Levomilnacipran nanostructured lipid carriers (LEV-NLC).
Methods: This study utilised a CCRD (Central Composite Rotatable Design) with a three-factor factorial design and three levels. It examined the particle size, zeta potential, and entrapment efficiency of LEV-NLC in relation to three independent variables: the ratio of aqueous to organic phase (X1), the ratio of drug to lipid (X2), and the concentration of surfactant (X3).