Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
We have previously shown in triple-negative breast cancer (TNBC) models that a triple therapy (TT) including intermittent cyclophosphamide (C), vinorelbine (V), and anti-PD-1 activates antigen-presenting cells (APC) and generates stem like-T cells able to control local and metastatic tumor progression. In the present manuscript, we report the generation of a highly aggressive, anti-PD-1 resistant model of a high-grade, Myc-driven B-cell non-Hodgkin's lymphoma (NHL) that can be controlled in vivo by TT but not by other chemotherapeutic agents, including cytarabine (AraC), platinum (P), and doxorubicin (D). The immunological memory elicited in tumor-bearing mice by TT (but not by other treatments) can effectively control NHL re-challenge even at very high inoculum doses. TT re-shaped the landscape of circulating innate NK cells and adaptive immune cells, including B and T cells, and significantly reduced exhausted CD4 and CD8 TIM3PD-1 T cells in the spleens of treated mice.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095342 | PMC |
| http://dx.doi.org/10.3390/jcm12072535 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
[Positron emission tomography-negative hemophagocytic lymphohistiocytosis in two patients with aggressive B-cell lymphoma].
Inn Med (Heidelb)
August 2025
Klinik für Infektiologie, St. Joseph Krankenhaus Berlin-Tempelhof, Wüsthoffstraße 15, 12101, Berlin, Deutschland.
Introduction: Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome caused by various diseases, with lymphoma being one of the most important triggers. Positron emission tomography/computed tomography (PET/CT) is considered an important tool in establishing the etiology of HLH.
Case Descriptions: We present two cases of HLH caused by diffuse large B‑cell lymphoma (DLBCL) in which 18F-fluorodeoxyglucose (18F-FDG) PET/CT showed no abnormal FDG uptake.
Secondary Central Nervous System Lymphoma Involving Meninges: A Rare Case Report and a Comprehensive Review of Peripheral T-Cell Lymphoma, Not Otherwise Specified.
J Med Cases
July 2025
Department of Hematology Oncology, Decatur Morgan Hospital, Decatur, AL 35601, USA.
Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS), is a rare and aggressive subtype of non-Hodgkin lymphoma (NHL) that arises from mature T or natural killer (NK) cells, accounting for about 5% of all NHL cases. While PTCL-NOS typically involves lymph nodes, extranodal sites such as the skin, gastrointestinal tract, liver, and lungs can also be affected. Central nervous system (CNS) involvement is extremely rare, especially at the time of initial presentation.
View Article and Find Full Text PDFAtypical Presentation of Diffuse Large B-Cell Lymphoma of the Caecum in a Young Patient: A Case Report.
Cureus
June 2025
Pathology, Monash Health, Clayton, AUS.
Primary diffuse large B-cell lymphoma (DLBCL) of the colon, particularly involving the caecum, is rare and often poses a diagnostic challenge due to its non-specific presentation and the low incidence of colorectal involvement. Early recognition is crucial, as timely diagnosis and multidisciplinary management can significantly improve patient outcomes. A 29-year-old female presented with a two-week history of intermittent lower abdominal pain, progressive abdominal bloating, weight loss, night sweats, and bilateral ankle swelling over the last four weeks.
View Article and Find Full Text PDFLupus nephritis in Mexican patients: Response to intensive therapy.
Reumatol Clin (Engl Ed)
May 2025
Hospital Central "Dr. Ignacio Morones Prieto" y Facultad de Medicina de la Universidad Autónoma de San Luis Potosí, Mexico. Electronic address:
Introduction: lupus nephritis represents a challenge in treatment. In spite of intensive therapy, is common a sustained renal incomplete response.
Objective: To describe different responses to adequate/intensive treatment to lupus nephritis.
A Cytokine Storm Unveiled: Diagnostic Challenges of Macrophage Activation Syndrome in the Context of Undiagnosed Systemic Lupus Erythematosus in an Adolescent.
Ann Afr Med
June 2025
Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pune, Maharashtra, India.
Macrophage activation syndrome (MAS) is part of a spectrum of cytokine storms. This case report describes a presentation of an 18-year-old female with systemic lupus erythematosus (SLE) complicated by MAS. The patient, previously healthy, presented with a 3-week history of high-grade intermittent fever, abdominal pain, nausea, and loss of appetite.
View Article and Find Full Text PDF