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http://dx.doi.org/10.1001/jama.2023.1435 | DOI Listing |
Cureus
July 2025
Orthopaedics, Rothman Orthopaedic Institute at Thomas Jefferson University, Philadelphia, USA.
Introduction: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are increasingly prescribed for glycemic control and weight loss, but their effects on surgical outcomes remain incompletely understood. Delayed gastric emptying and associated perioperative risks have prompted updated anesthetic guidelines, although evidence in orthopaedic or hand surgery remains limited. This study aims to evaluate the prevalence of GLP-1 RA use and its perioperative implications among patients undergoing surgical fixation for distal radius fractures (DRFs).
View Article and Find Full Text PDFCureus
July 2025
Electrocardiology and Clinical Cardiac Electrophysiology, University of Arkansas for Medical Sciences, Little Rock, USA.
Sinus bradycardia is defined as a heart rate of less than 60 beats per minute (bpm), and it can be attributed to many etiologies, some of which are reversible, including but not limited to acute coronary syndrome, active infections, electrolyte imbalances, hypothyroidism, and medications. We report the case of a 64-year-old man who was admitted to the intensive care unit for the management of status epilepticus, where he developed new-onset, life-threatening sinus bradycardia, requiring placement on support with two inotropic agents (epinephrine and dopamine) due to persistent hemodynamic instability. Cardiology was consulted as a result, and after extensive workup, including review of past medical conditions, laboratory testing, and telemetry review, including that for reversible etiologies, we identified one of the antiepileptic agents on his medication list as the culprit of his sinus bradycardia.
View Article and Find Full Text PDFCureus
July 2025
Department of Medicine, Olive View - University of California Los Angeles Medical Center, Los Angeles, USA.
Introduction The use of complementary and alternative medicine is prevalent among individuals living with chronic pain. Artri King and similarly branded over-the-counter supplements are advertised as natural arthritis pain relievers but have been found to contain hidden prescription drugs including dexamethasone, diclofenac, and methocarbamol. These unbranded pharmaceutical agents may pose significant health risks, particularly when used without clinical oversight or in combination with other therapies.
View Article and Find Full Text PDFPain Physician
July 2025
Pain Management Centers of America, Evansville, IN; Department of Anesthesiology and Perioperative Medicine, University of Louisville School of Medicine, Louisville, KY; Indiana University School of Medicine, Evansville, IN.
Background: Physician payments have declined significantly due to budget neutrality rules and reimbursement cuts. Since 2001, Medicare payments to physicians have dropped by 33% when adjusted for inflation. These reductions have been compounded by 2% annual sequestration cuts introduced after the Affordable Care Act (ACA), which continues through 2032.
View Article and Find Full Text PDFJ Cancer Res Clin Oncol
August 2025
AstraZeneca Farmacéutica Spain, Madrid, Spain.
Purpose: We aimed to evaluate adherence to oral antineoplastic therapy (OAT) in patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) and its potential relationship with several clinical outcomes.
Methods: Observational, prospective, multicenter study performed by 6 hospital pharmacists in Spain. The primary outcome was the proportion of treatment adherence as evaluated by pill reconciliation during the 3-month active follow-up period.