Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Context: The bone-derived adipokine lipocalin-2 is relevant for body weight regulation by stimulating the leptin-melanocortin pathway.
Objective: We aimed to (i) detect variants in the lipocalin-2 gene () which are relevant for body weight regulation and/or anorexia nervosa (AN); (ii) describe and characterize the impact of and variants on circulating lipocalin-2 level.
Methods: Sanger sequencing of the coding region of in 284 children and adolescents with severe obesity or 287 patients with anorexia nervosa. analyses to evaluate functional implications of detected variants. TaqMan assays for rare non-synonymous variants (NSVs) in additional independent study groups. Serum levels of lipocalin-2 were measured by ELISA in 35 females with NSVs in either or , and 33 matched controls without NSVs in the two genes.
Results: Fourteen -variants (five NSVs) were detected. -p.Leu6Pro and p.Gly9Val located in the highly conserved signal peptide region may induce functional consequences. The secondary structure change of lipocalin-2 due to 2-p.Val89Ile may decrease solubility and results in a low lipocalin-2 level in a heterozygotes carrier (female recovered from AN). Lean individuals had lower lipocalin-2 levels compared to patients with obesity ( = 0.033).
Conclusion: Lipocalin-2 levels are positively associated with body mass index (BMI). Single -variants might have a profound effect on lipocalin-2 levels.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10071025 | PMC |
| http://dx.doi.org/10.3389/fendo.2023.1137308 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Does cognitive functioning improve with weight restoration? An examination of changes in intelligence quotient scores in adolescents with anorexia nervosa before and after treatment.
Eat Disord
September 2025
Department of Child and Adolescent Psychiatry and Behavioral Sciences, Children's Hospital of Philadelphia, Philadelphia Pennsylvania, United States of America.
Intelligence Quotient (IQ) scores, typically considered stable throughout life, may be impacted by anorexia nervosa (AN). This study investigated whether IQ scores change following treatment in adolescents with AN ( = 110; age = 14.65 ± 2.
View Article and Find Full Text PDFTrends in the prevalence of anorexia nervosa among individuals under 45 years in China, 1992-2021: an age-period-cohort analysis.
Front Public Health
September 2025
Integrated Care Management Center, Outpatient Department, West China Hospital, Sichuan University, Chengdu, China.
Objective: This study aims to analyze the temporal trends in the incidence and prevalence of anorexia nervosa (AN) in China from 1992 to 2021, focusing on age, period, and cohort effects, in order to provide evidence for the prevention and control of anxiety-related disorders.
Methods: Data on the incidence and prevalence of anorexia nervosa in China were obtained from the Global Burden of Disease Study 2021. Joinpoint regression analysis was employed to assess trends over time, while an age-period-cohort (APC) model was used to estimate the net effects of age, period, and cohort variables.
Association Between Cannabis Use and Neuropsychiatric Disorders: A Two-sample Mendelian Randomization Study.
Alpha Psychiatry
August 2025
Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, 130021 Changchun, Jilin, China.
Background: The progressive legalization and widespread use of cannabis has led to its use as a treatment for certain neuropsychiatric disorders. Traditional epidemiological studies suggest that cannabis use has an effect on some neurocognitive aspects. However, it is unclear whether cannabis use is causally related to common neuropsychiatric disorders.
View Article and Find Full Text PDFAssessing Severity in Anorexia Nervosa Using Alternative Criteria to the DSM-5 in a Cross-Sectional Study.
Int J Eat Disord
September 2025
Department of Emergency Psychiatry and Acute Care, Lapeyronie Hospital, Montpellier, France.
Objective: This study compared overvaluation of weight and shape (OWS), drive for thinness (DT), and their combination (OWS-DT) as alternative severity classifications for anorexia nervosa (AN) to the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) severity classification.
Method: 312 AN treatment-seeking outpatients (mean age = 26.8, SD = 10.
Tendencies of eating disordered behaviours in male content creators: a social media analysis.
J Eat Disord
September 2025
Center for Nutrition and Therapy (NuT), University of Applied Sciences Muenster, Corrensstraße 25, 48149, Muenster, Germany.
Eating disorders are primarily associated with women and an obsession with thinness. Recent research and social media content show that men are also concerned about their body image, striving for a muscular and athletic physique. To investigate eating disorder tendencies among male content creators with a mesomorphic body type (N = 26), a social media analysis was conducted on Instagram and TikTok over four weeks.
View Article and Find Full Text PDF