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Patient involvement in health research is rarely driven solely by patients, who could be considered to have the highest degree of investment in such research. In the Kidney Connect project, the patients have been the driving force. This commentary considers the following questions: How did we, as patients, lead the work as the driving force in the project? What went well and what did not go so well from our perspective? How did the project compare with work driven by researchers? We argue that projects driven solely by either patients or researchers each have their own limitations. Projects driven solely by patients have some limitations in their robustness, rigour, and likelihood of publication. Nevertheless, a project driven solely by patients has been able to produce findings that are broadly comparable to a project driven solely by researchers that employed methods ensuring robustness and rigour. We suggest collaboration between patients and researchers also for projects driven by patients.
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http://dx.doi.org/10.1186/s40900-023-00432-7 | DOI Listing |
CNS Drugs
September 2025
Global Health Neurology Lab, Sydney, NSW, 2150, Australia.
Acute ischemic stroke (AIS) remains a leading cause of mortality and long-term disability globally, with survivors at high risk of recurrent stroke, cardiovascular events, and post-stroke dementia. Statins, while widely used for their lipid-lowering effects, also possess pleiotropic properties, including anti-inflammatory, endothelial-stabilizing, and neuroprotective actions, which may offer added benefit in AIS management. This article synthesizes emerging evidence on statins' dual mechanisms of action and evaluates their role in reducing recurrence, improving survival, and mitigating cognitive decline.
View Article and Find Full Text PDFWorld J Microbiol Biotechnol
September 2025
Department of Microbiology, University of Georgia, Athens, GA, 30602, USA.
While PGPB have historically been applied in agriculture, their formal recognition in the last century has driven intensive research into their role as sustainable tools for improving crop yield and stress tolerance. As they are primarily sourced from wild or native environments, the widespread enthusiasm has led to heightened expectations surrounding their potential, often based on the assumption that biological solutions are inherently safer and more effective than synthetic inputs. However, despite their popularity, increasing reports of inconsistent or limited performance under real-world, field conditions have raised critical questions about their credibility as biofertilizers and biocontrol agents.
View Article and Find Full Text PDFDiabetologia
September 2025
Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
Aims/hypothesis: Alpha cell dysregulation is an integral part of type 2 diabetes pathophysiology, increasing fasting as well as postprandial glucose concentrations. Alpha cell dysregulation occurs in tandem with the development of insulin resistance and changes in beta cell function. Our aim was to investigate, using mathematical modelling, the role of alpha cell dysregulation in beta cell compensatory insulin secretion and subsequent failure in the progression from normoglycaemia to type 2 diabetes defined by ADA criteria.
View Article and Find Full Text PDFCardiovasc Diabetol
September 2025
Computational Biomedicine, Center for Thrombosis and Hemostasis (CTH), Mainz, Germany.
Background: Sodium-glucose cotransporter 2 (SGLT2) inhibitors, such as Empagliflozin, are antidiabetic drugs that reduce glucose levels and have emerged as a promising therapy for patients with heart failure (HF), although the exact molecular mechanisms underlying their cardioprotective effects remain to be fully elucidated. The EmDia study, a randomized, double-blind trial conducted at the University Medical Center of Mainz, has confirmed the beneficial effects of Empagliflozin in HF patients after both one and twelve weeks of treatment. In this work, we aimed to assess whether changes in lipid profiles driven by Empagliflozin use in HF patients in the EmDia trial could assist in gaining a better understanding of its cardioprotective mechanisms.
View Article and Find Full Text PDFArch Environ Contam Toxicol
September 2025
Department of Environmental Engineering, Faculty of Engineering and Natural Sciences, Bursa Technical University, Mimar Sinan Mahallesi Mimar Sinan Bulvarı Eflak Caddesi No:177, 16310, Yıldırım, Bursa, Turkey.
This study investigates airborne concentrations of six insecticides widely used on crops grown in agricultural, semi-urban, and rural areas of Bursa Province, Türkiye. Sorbent-impregnated passive air samplers (SIP-PASs), consisting of polyurethane foam (PUF) disks impregnated with XAD-2 resin, were deployed at ten strategically selected sites representing diverse agricultural and demographic profiles within the province. Analytes were quantified using gas chromatography-mass spectrometry (GC-MS) for depuration compounds and liquid chromatography-tandem mass spectrometry (LC-MS/MS) for target insecticides.
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