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http://dx.doi.org/10.1016/j.ijrobp.2023.03.065 | DOI Listing |
Clin Cancer Res
August 2025
Memorial Sloan Kettering Cancer Center, New York, New York, United States.
Purpose: Patients with extensive-stage small cell lung cancer (ES-SCLC) are commonly treated with induction systemic therapy and consolidative thoracic radiation therapy (TRT). PARP inhibitors have demonstrated radiosensitization in preclinical lung cancer models. We performed an investigator-initiated, multi-institutional, single-arm, open label phase I study of concurrent olaparib with TRT.
View Article and Find Full Text PDFInt J Phytoremediation
August 2025
Institute of Botany, University of the Punjab, Lahore, Pakistan.
Tannery solid waste poses significant environmental challenges owing to its high metal content, especially Cr. Converting this waste into value-added byproduct biochar offers a sustainable management approach to reducing the waste load on landfill sites and also guarding the nearby fauna, flora and water bodies. This study aimed to develop metal-resistant microbial consortium loaded biochar (MCLB) by inoculating tannery solid waste biochar (BC) with consortium of ten and/or five strains and their effect was evaluated on the morphological and biochemical attributes of sunflowers including metals immobilization.
View Article and Find Full Text PDFJ Agric Food Chem
August 2025
Department of Chemistry, Faculty of Science, National University of Singapore, 3 Science Drive 3, Singapore 117543, Singapore.
Nanozymes are synthetic enzymes that mimic natural enzymes with superior stability and cost-efficiency. Organic-dominated nanozymes overcome key limitations of inorganic variants, such as toxicity and environmental persistence, by offering biocompatible alternatives. Their applications in sustainable agriculture include pesticide sensing, nutrient management, and soil health monitoring.
View Article and Find Full Text PDFPLoS One
August 2025
SoilsWest, Center for Sustainable Farming Systems, Food Futures Institute, Murdoch University, Australia.
Herbicide residues in soil from previous crops or from pre-emergent treatments can have unintended toxicity on the next crop. Despite this there is limited published information on toxicity thresholds for many crops or herbicides. This study aimed to quantify shoot and root responses of six common winter grains crops (canola, chickpea, fieldpea, lentil, lupin and wheat) to increasing concentration of four common herbicides (clopyralid, pyroxasulfone, propyzamide and trifluralin) in soil.
View Article and Find Full Text PDFFront Immunol
August 2025
Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Background: The prognosis of metastatic or recurrent hepatocellular carcinoma (HCC) remains poor, and new treatment strategies are warranted. Despite promising preclinical results demonstrating that radiation primes the immune system and produces a synergistic antitumor response for long-term disease control, limited clinical data are available. Therefore, in this study, we investigated the efficacy and safety of combining radiotherapy with immune checkpoint inhibitors (ICIs) for patients with metastatic and recurrent HCC in a real-world setting.
View Article and Find Full Text PDF