Community-Based Service Use After Clozapine Treatment: A Mirror-Image Analysis of Public Claims Data.

Psychiatr Serv

Department of Psychiatry (Sarpal, Gannon, Chengappa) and Department of Pharmacy and Therapeutics (Suh), University of Pittsburgh, Pittsburgh; Allegheny County Department of Human Services, Pittsburgh (Bian, Ko, Jhon).

Published: October 2023


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Article Abstract

Although clozapine demonstrates unique efficacy for treatment-resistant schizophrenia, its impact on community-based services remains largely underexplored. The authors examined changes in use of community-based services after clozapine treatment among a sample of 163 patients with schizophrenia by using public claims data in Allegheny County, Pennsylvania. Mirror-image analyses of service utilization were used to compare the 180-day period before treatment initiation with the 180-day period that began after 6 months of adherent treatment, accounting for age, race, and gender. Across demographic variables, clozapine treatment was associated with increased use of community-based services and decreased use of psychiatric inpatient services (p<0.05, Bonferroni corrected), suggesting that clozapine treatment shifts service needs from emergency care to community-based care and recovery.

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http://dx.doi.org/10.1176/appi.ps.20220471DOI Listing

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