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Stroke is the third leading cause of death and disability overall worldwide. Upper limb impairment is a common consequence for stroke survivors, having negative impact on their quality of life. Robotic rehabilitation, through repetitive and monitored movements, can improve their status. Developed by a team of researchers at Politecnico di Milano, AGREE is an exoskeleton for upper limb rehabilitation at the stage gate between translational research and clinical validation. Since the cost of this device is particularly high, the present study aimed to provide a framework for assessing its value. The Social Return on Investment (SROI) method, able to grasp the economic, social and environmental impact of an activity, was applied, using expert opinions of a pool of clinical engineers and healthcare professionals from different Italian hospitals to obtain information. Environmental impacts were estimated through Life Cycle Assessment in terms of CO emissions and incorporated in the analysis. Considering a 5-year period, the SROI for a single exoskeleton was 3.75:1, and the SROI for the number of exoskeletons projected to be sold was 2.868:1, thus resulting largely in value for money. This study provides a model for combining economic, social and environmental outcomes that, besides contributing to theory, could be useful for decision-making.
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http://dx.doi.org/10.3390/ijerph20065224 | DOI Listing |
J Fish Biol
September 2025
School of Biodiversity, One Health & Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
The harvest of animals from the wild is a pervasive selective force, especially in fisheries, where harvesting often targets individuals with specific traits. While most research has focused on large-scale commercial or recreational fisheries, little attention has been paid to artisanal fisheries, particularly those targeting ornamental species. Furthermore, environmental factors such as temperature and oxygen levels influence the behaviour of fishes, such as boldness and sociability, but their role in the harvesting process remains poorly understood.
View Article and Find Full Text PDFToxicol Lett
September 2025
Mammalian Embryology, Department of Life Science, Faculty of Science and Engineering, Kindai University 3-4-1, Kowake, Higashiosaka, Osaka 577-8501, Japan. Electronic address:
Autism spectrum disorder (ASD) is a developmental disability characterized by impaired social communication and repetitive behaviors, and environmental and genetic factors are involved in its onset. The use of the antiepileptic drug valproic acid (VPA) during pregnancy is associated with neural tube defects and developmental disorders in the fetus. In this study, we aimed to identify abnormalities in cortical morphogenesis owing to prenatal VPA exposure and to elucidate the abnormalities in brain function associated with these abnormalities, particularly by comparing multiple and single environments.
View Article and Find Full Text PDFProg Neuropsychopharmacol Biol Psychiatry
September 2025
Department of Women's and Children's Health, SciLifeLab, Uppsala University, Sweden. Electronic address:
Estrogens are suggested to affect mood by binding to widespread estrogen receptors in the brain and therewith modulating a variety of neurosignaling pathways. Single nucleotide polymorphisms (SNPs) in the genes encoding estrogen receptors might influence these actions and thereby play a role in the genetic foundation of mood disorders. Several SNPs in the estrogen receptor 1 (ESR1) gene have been studied in relation to anxiety and depression, while confounders and interaction with psychosocial factors have largely been overlooked.
View Article and Find Full Text PDFJ Environ Manage
September 2025
School of Industrial Engineering, Iran University of Science and Technology, Tehran, Iran.
Agricultural supply chains face significant challenges in achieving food security and sustainability, particularly due to climate change and waste production. Effectively managing these supply chains, especially in the context of uncertainties, is crucial for optimizing resource use and minimizing waste. This research develops a multi-objective optimization for designing a sustainable and responsive closed-loop agricultural supply chain network, focusing on jujube products under uncertain conditions.
View Article and Find Full Text PDFActa Psychol (Amst)
September 2025
School of Foreign Languages, Taizhou University, Jiangsu Province, PR China. Electronic address:
One of the primary goals of second language (L2) instruction is to enable students to actively engage in L2 communication, with willingness to communicate (WTC) serving as a critical antecedent that facilitates such communicative behavior. Therefore, research on L2 students' WTC (L2 WTC) is gaining sustained attention in recent years. A variety of personality (e.
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