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The main objective was to assess the feasibility of an intensive rehabilitation program (IRP) for stroke patients; and secondly, to detect eventual age-related differences in content, duration, tolerability, and safety in a prospective observational cohort of patients diagnosed with subacute stroke, admitted to inpatient rehabilitation (BRAIN-CONNECTS project). Activities during physical, occupational and speech therapy, and time dedicated to each one were recorded. Forty-five subjects (63.0 years, 77.8% men) were included. The mean time of therapy was 173.8 (SD 31.5) minutes per day. The only age-related differences when comparing patients ≥65 and <65 years were a shorter time allocated for occupational therapy (-7.5 min (95% CI -12.5 to -2.6), = 0.004) and a greater need of speech therapy (90% vs. 44%) in the older adults. Gait training, movement patterns of upper limbs, and lingual praxis were the most commonly performed activities. Regarding tolerability and safety, there were no losses to follow-up, and the attendance ratio was above 95%. No adverse events occurred during any session in all patients. Conclusion: IRP is a feasible intervention in patients with subacute stroke, regardless of age, and there are no relevant differences on content or duration of therapy.
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http://dx.doi.org/10.3390/ijerph20064696 | DOI Listing |
JAMA Netw Open
September 2025
School of Rehabilitation Science, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
Importance: The cost-effectiveness of adding early in-bed cycling to usual physiotherapy among adults receiving mechanical ventilation in the intensive care unit (ICU) compared with usual physiotherapy alone is unknown.
Objective: To evaluate the cost-effectiveness of in-bed cycling plus usual physiotherapy compared with usual therapy alone in the Critical Care Cycling to Improve Lower Extremity Strength (CYCLE) randomized clinical trial.
Design, Setting, And Participants: This trial-based economic evaluation with a 90-day time horizon compared early cycling plus usual physiotherapy vs usual physiotherapy alone from a societal perspective.
Phys Occup Ther Pediatr
September 2025
School of Rehabilitation Therapy, Department of Pediatrics, Queen's University, Kingston, ON, Canada.
Aim: To explore oral feeding management practices, specifically initiation and advancement of oral feeds, across level II and III neonatal intensive care units (NICUs) in Canada.
Methods: A national online survey was conducted across 65 NICUs (34 level II, 31 level III), which included questions on hospital demographics and clinical approaches for initiating, advancing, and managing oral feeds. A descriptive analysis was performed on the responses.
J Biochem Mol Toxicol
September 2025
Department of Rehabilitation Medicine, Hebei Engineering University Affiliated Hospital, Handan, Hebei, China.
Blood-Brain Barrier (BBB) dysfunction acts as a key mediator of ischemic brain injury, contributing to brain edema, inflammatory cell infiltration, and neuronal damage. The integrity of the BBB is largely maintained by tight junction proteins, such as Claudin-5, and its disruption exacerbates neurological deficits. Neurokinin B (NKB), a neuropeptide that belongs to the tachykinin family, has been implicated in various physiological processes, including neuroinflammation and vascular function.
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August 2025
Division of Neonatology, Center for Maternal-Neonatal Care, Nagoya University Hospital, Nagoya, JPN.
This case report describes the implementation of Family-Centered Care (FCC) and developmental occupational therapy (OT) for an extremely preterm infant born at 22 weeks and one day of gestation, weighing 448 g. The infant experienced multiple complications, including necrotizing enterocolitis, sepsis, intraventricular hemorrhage, and respiratory distress, requiring prolonged intensive care. Due to physiological fragility and immature neurobehavior, a structured rehabilitation approach was introduced, integrating OT and caregiver participation based on FCC principles.
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September 2025
Research, Rinaldi Fontani Foundation, Florence, ITA.
Stroke remains a leading cause of long-term disability worldwide, and early intervention is critical for optimizing neurorehabilitative outcomes by capitalizing on the heightened neuroplasticity of the acute and subacute phases. This study aimed to evaluate whether the integration of Radio Electric Asymmetric Conveyer (REAC) neurobiological modulation protocols, Neuro Postural Optimization (NPO) and Neuro Muscular Optimization (NMO), into early post-stroke rehabilitation can accelerate and enhance functional recovery compared to conventional rehabilitation alone. Thirteen patients (nine males, four females; age range: 56-86 years; mean: 74) received a single NPO session, followed by an intensive cycle of 10 NMO sessions distributed over five to six consecutive days.
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