Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Download full-text PDF

Source
http://dx.doi.org/10.7326/L22-0490DOI Listing

Publication Analysis

Top Keywords

good publication
4
publication practice
4
practice gpp
4
gpp guidelines
4
guidelines company-sponsored
4
company-sponsored biomedical
4
biomedical 2022
4
2022 update
4
good
1
practice
1

Similar Publications

Half-life prediction of central nervous system (CNS) small molecules in humans using gradient tree boosting.

Future Med Chem

September 2025

Computational Science & Artificial Intelligence, Xenon Pharmaceuticals Inc, Burnaby, BC, Canada.

Aims: To develop a machine learning (ML) model for early-stage prediction of human half-life of oral central nervous system (CNS) drugs and to establish a curated dataset, including key and data, to support future modeling efforts.

Materials & Methods: Human and rat half-life, plasma protein binding (PPB), and liver microsomal clearance (LM) data for 76 diverse CNS drugs and candidates were obtained from public sources or evaluated at WuXi AppTec. Gradient tree boosting (GTB) models were constructed using ChemAxon's Trainer Engine.

View Article and Find Full Text PDF

Background: Population surveys on child wellbeing require a brief, validated tool to measure child and adolescent maltreatment. The 7-item Short Child Maltreatment Questionnaire (SCMQ), developed by a WHO expert committee, has not been psychometrically tested.

Objective: This study aimed to determine the factor structure, measurement invariance and correlates of a modified version of the SCMQ (6 of its 7 items) in a sample of adolescents attending schools in England.

View Article and Find Full Text PDF

Introduction: Chronic rhinosinusitis with nasal polyp (CRSwNP) is a predominant type 2 inflammatory disease, affecting the sense of smell and quality of life. Loss of smell compromises physical and emotional health, creating negative impacts and its treatment in CRSwNP is challenging.

Aim: To present the outcomes of dupilumab in olfactory function, Nasal Polyp Score (NPS) and quality of life in Brazilian patients with severe CRSwNP.

View Article and Find Full Text PDF

Aim: To examine the association of family-centered care (FCC) with oral health indicators among children with special health care needs (CSHCN).

Methods: Data includes the CSHCN population from the 2017 to 2019 National Survey of Children's Health (NSCH). Four parent- and caregiver-reported binary oral health outcomes were assessed: preventive dental visits (PDVs), cavities, condition of teeth, and oral health problems.

View Article and Find Full Text PDF

The increasing prevalence of overweight/obesity among the elderly has significant implications for oral health due to shared pathophysiological mechanisms. Despite its importance, comprehensive reviews on this topic remain limited. This study investigates the association between overweight/obesity and oral health outcomes in adults aged 55 and older.

View Article and Find Full Text PDF