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http://dx.doi.org/10.7326/L22-0490 | DOI Listing |
Future Med Chem
September 2025
Computational Science & Artificial Intelligence, Xenon Pharmaceuticals Inc, Burnaby, BC, Canada.
Aims: To develop a machine learning (ML) model for early-stage prediction of human half-life of oral central nervous system (CNS) drugs and to establish a curated dataset, including key and data, to support future modeling efforts.
Materials & Methods: Human and rat half-life, plasma protein binding (PPB), and liver microsomal clearance (LM) data for 76 diverse CNS drugs and candidates were obtained from public sources or evaluated at WuXi AppTec. Gradient tree boosting (GTB) models were constructed using ChemAxon's Trainer Engine.
Child Abuse Negl
September 2025
Department of Psychiatry, University of Oxford, Oxford, UK.
Background: Population surveys on child wellbeing require a brief, validated tool to measure child and adolescent maltreatment. The 7-item Short Child Maltreatment Questionnaire (SCMQ), developed by a WHO expert committee, has not been psychometrically tested.
Objective: This study aimed to determine the factor structure, measurement invariance and correlates of a modified version of the SCMQ (6 of its 7 items) in a sample of adolescents attending schools in England.
Braz J Otorhinolaryngol
September 2025
Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo, São Paulo, SP, Brazil.
Introduction: Chronic rhinosinusitis with nasal polyp (CRSwNP) is a predominant type 2 inflammatory disease, affecting the sense of smell and quality of life. Loss of smell compromises physical and emotional health, creating negative impacts and its treatment in CRSwNP is challenging.
Aim: To present the outcomes of dupilumab in olfactory function, Nasal Polyp Score (NPS) and quality of life in Brazilian patients with severe CRSwNP.
Spec Care Dentist
September 2025
Department of Health Services Research and Administration, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Aim: To examine the association of family-centered care (FCC) with oral health indicators among children with special health care needs (CSHCN).
Methods: Data includes the CSHCN population from the 2017 to 2019 National Survey of Children's Health (NSCH). Four parent- and caregiver-reported binary oral health outcomes were assessed: preventive dental visits (PDVs), cavities, condition of teeth, and oral health problems.
Geroscience
September 2025
Department of Orofacial Pain and Dysfunction, Academic Centre for Dentistry Amsterdam (ACTA) University of Amsterdam and Vrije Universiteit Amsterdam, Gustav Mahlerlaan, 3004, 1081 LA, Amsterdam, the Netherlands.
The increasing prevalence of overweight/obesity among the elderly has significant implications for oral health due to shared pathophysiological mechanisms. Despite its importance, comprehensive reviews on this topic remain limited. This study investigates the association between overweight/obesity and oral health outcomes in adults aged 55 and older.
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