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http://dx.doi.org/10.7326/L23-0049 | DOI Listing |
Arch Cardiovasc Dis
September 2025
Department of Orthopaedics, Shaoxing Keqiao Women & Children's Hospital, Shaoxing 312030, Zhejiang, China. Electronic address:
Background: Sacubitril/valsartan is a widely used cardiovascular agent characterized by its dual inhibition of the renin-angiotensin-aldosterone system and neprilysin. However, existing evidence on the safety of sacubitril/valsartan is primarily limited to clinical studies; this results in an inability to provide a timely update on associated adverse events.
Aim: To mine and systematically describe adverse events related to sacubitril/valsartan from September 2015 to June 2024 using the Food and Drug Administration Adverse Event Reporting System (FAERS) database.
Mol Genet Metab Rep
September 2025
Quest Diagnostics Nichols Institute, San Juan Capistrano, CA 92675, USA.
Objectives: Quality control (QC) in clinical laboratory is critical to ensuring quality and accuracy of patient results. However, QC monitoring is complicated in the multi-analyte, multi-instrument assays common to biochemical genetics laboratories. Comprehensive off-the-shelf QC management systems optimized for such highly complex assays and platforms are relatively scarce.
View Article and Find Full Text PDFBMC Med Inform Decis Mak
August 2025
Department of Nephrology and Kidney Research Institute, West China Hospital, Sichuan University, No. 37 Guoxue Xiang, Chengdu, Sichuan, 610041, China.
Regional citrate anticoagulation (RCA) is critical for extracorporeal anticoagulation in continuous renal replacement therapy done at the bedside. To make patients' data more secure and to help with computer-based monitoring of dosages, we suggest a system that uses machine learning. This system will give early alerts about citric acid overdose and advise changes to how much citrate and calcium gluconate are infused into the patient's body.
View Article and Find Full Text PDFInt J Environ Res Public Health
August 2025
Climate Change and Health Office, Health Canada, Government of Canada, Ottawa, ON K1A 0K9, Canada.
It is critical to inform the public of the threat heat poses to health and provide actionable guidance on mitigating this risk before, during, and after heat events. To help educate the public during heat events, Health Canada works closely with Environment and Climate Change Canada (ECCC) to distribute heat-health messaging through a weather warning system. However, the warning system's current list of messages dates back over a decade.
View Article and Find Full Text PDFEuro Surveill
August 2025
Centers for Disease Control and Prevention, Fort Collins, Colorado, United States.
A live attenuated chikungunya vaccine (IXCHIQ) received licensure in the United States (US) for ≥ 18-year-olds in November 2023. Post-licensure safety surveillance identified 28 adverse events in 2024 among US persons, including six neurological or cardiac serious adverse events (SAEs) in males ≥ 65 years. In early 2025, providers were alerted, a precaution for older persons was issued and vaccine guidance was updated.
View Article and Find Full Text PDF