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Article Abstract
Growing evidence suggests that phase-locked deep brain stimulation (DBS) can effectively regulate abnormal brain connectivity in neurological and psychiatric disorders. This letter therefore presents a low-power SoC with both neural connectivity extraction and phase-locked DBS capabilities. A 16-channel low-noise analog front-end (AFE) records local field potentials (LFPs) from multiple brain regions with precise gain matching. A novel low-complexity phase estimator and neural connectivity processor subsequently enable energy-efficient, yet accurate measurement of the instantaneous phase and cross-regional synchrony measures. Through flexible combination of neural biomarkers such as phase synchrony and spectral energy, a four-channel charge-balanced neurostimulator is triggered to treat various pathological brain conditions. Fabricated in 65-nm CMOS, the SoC occupies a silicon area of 2.24 mm and consumes 60 W, achieving over 60% power saving in neural connectivity extraction compared to the state-of-the-art. Extensive measurements demonstrate multi-channel LFP recording, real-time extraction of phase and neural connectivity measures, and phase-locked stimulation in rats.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9997065 | PMC |
| http://dx.doi.org/10.1109/lssc.2023.3238797 | DOI Listing |
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