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Purpose: The purpose of this study was to report a case with bilateral paravascular inner retinal defects (PIRDs) enlarging with progressive myopia, which had different structural characteristics from the glaucomatous retinal nerve fiber layer (RNFL) defect.
Patients And Methods: A 10-year-old girl with high myopia was referred to a glaucoma clinic for evaluation of RNFL defects shown in color fundus photographs. Fundus photographs and optical coherence tomography examinations were serially reviewed to examine the changes in the RNFL.
Results: Cleavage of inner retinal layers involving the layers deeper than the RNFL was identified in optical coherence tomography, which appeared and enlarged in both eyes along with progressive myopia and axial elongation during the follow-up period of 8 years.
Conclusions: PIRD developed and enlarged with progressive myopia and axial elongation in childhood. It should be differentiated from the widening of RNFL defect shown with glaucoma progression.
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http://dx.doi.org/10.1097/IJG.0000000000002201 | DOI Listing |
FASEB J
September 2025
Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Age-related cataract (ARC) represents a major global cause of visual impairment, with ultraviolet B (UVB) radiation recognized as a primary contributor to oxidative damage in the lens. FOXO3, a key regulator of aging, apoptosis, and oxidative stress-induced cell death, was investigated for its role and regulatory mechanisms in UVB-induced oxidative stress using human lens epithelial cells (HLECs). A progressive decrease in FOXO3 protein expression was observed in the lens capsules across various stages of cataract progression, as well as in UVB-exposed animal models and UVB-treated HLECs.
View Article and Find Full Text PDFZhonghua Yan Ke Za Zhi
September 2025
Beijing Tongren Eye Center, Beijing Institute of Ophthalmology, Beijing Ophthalmology&Visual Sciences Key Lab, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
Pathological myopia is one of the primary causes of irreversible visual loss in the population. Myopic maculopathy represents a key feature of pathological myopia, among which macular atrophy is the main contributor to severe visual impairment. The specific mechanism underlying the development of macular atrophy remains unclear.
View Article and Find Full Text PDFVestn Oftalmol
September 2025
Azerbaijan Medical University, Baku, Azerbaijan.
Objective: This study evaluated changes in ocular parameters in patients with progressive myopia receiving 0.01% atropine.
Material And Methods: The study included 35 children (18 girls, 51.
Front Ophthalmol (Lausanne)
August 2025
Aier Eye Institute, Changsha, China.
High myopia is a global health concern, often leading to degenerative retinal changes known as myopic retinopathy. Although mechanical stress, hypoperfusion, extracellular matrix remodeling, and growth factor dysregulation have been implicated in the pathogenesis of myopic retinopathy, emerging evidence highlights the critical role of chronic low-grade inflammation. Both innate and adaptive immune systems participate in myopic retinopathy through systemic and local inflammation.
View Article and Find Full Text PDFBMJ Case Rep
September 2025
Pediatrics, Strabismus and Neuro-ophthalmology, L V Prasad Eye Institute, MTC Campus, Bhubaneswar, Odisha, India
Myopic strabismus fixus (MSF) is an acquired, progressive form of strabismus associated with high myopia. It is typically characterised by an esotropia-hypotropia or exotropia-hypotropia complex. We present a sporadic case of a middle-aged adult male with high myopia, who exhibited an esotropia-hypertropia complex in both eyes.
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