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http://dx.doi.org/10.23736/S0375-9393.22.16868-9 | DOI Listing |
Cureus
August 2025
Internal Medicine, Centro Médico Nacional Siglo XXI, Mexico City, MEX.
Acute generalized exanthematous pustulosis (AGEP) is a rare, potentially severe cutaneous adverse reaction characterized by the rapid onset of numerous small, sterile pustules on edematous erythema, commonly accompanied by systemic symptoms such as high-grade fever and neutrophilic leukocytosis. AGEP is most frequently triggered by medications, especially antibiotics, though infections and other exposures can also be causative. We report the case of a previously healthy 27-year-old male patient who developed a febrile pustular eruption with systemic involvement.
View Article and Find Full Text PDFContour Tunable Resurfacing Laser (TRL™) is an erbium: yttrium aluminum garnet (YAG) fully ablative laser commonly used to treat the delicate lower eyelid skin for undereye rejuvenation. Post-treatment patients experience discomfort and extensive downtime. This pilot study incorporated an innovative post-procedure treatment that addresses patient concerns to skin rejuvenation procedures to improve patient relief and recovery, while improving patient retention.
View Article and Find Full Text PDFBackground: Energy-based devices are commonly used to improve the appearance of aging skin. Treatments can involve long recovery times, marked by pain, erythema, edema, and purpura, which is often a limiting factor in a patient’s willingness to undergo a procedure.
Objective: This study evaluated the safety and effectiveness of an Angiopoietin-1 derived QHREDGS peptide (Q-peptide) hydrogel and ointment, in comparison to a peptide-free control, in enhancing healing and patient satisfaction after radiofrequency microneedling (RFMN) treatment.
Dermatology
September 2025
Department of Clinical Pharmacology and Toxicology, University of Geneva, Geneva, Switzerland.
Introduction: Non-transient erythema (NTE) is a major feature of rosacea, but its clinical evaluation is subject to human investigator variability. The angiopoietin-TIE2 receptor tyrosine kinase pathway plays a key role in regulating vascular homeostasis, but was previously overlooked as a target for rosacea therapy. Angiopausin® is a patented plant-based ingredient identified through a molecular phytotherapy screening program as a positive inducer of the angiopoietin-TIE2 pathway, which is the "gatekeeper of vascular quiescence.
View Article and Find Full Text PDFCureus
August 2025
Internal Medicine, Larkin Community Hospital Palm Springs Campus, Hialeah, USA.
Periorbital cellulitis and angioedema can present with similar clinical features, posing a diagnostic challenge. We describe a case of a 71-year-old female patient with a past history of hypertension and diabetes who developed facial swelling and erythema following trauma. She was initially treated for periorbital cellulitis but was later found to have concurrent angioedema, likely triggered by antibiotics and herbal supplements.
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