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http://dx.doi.org/10.1097/LVT.0000000000000117 | DOI Listing |
Stroke
September 2025
Department of Neurology, Yale University School of Medicine, New Haven, CT. (L.S.B.B., A.L.H., H.E.B., C.W.J., J.G., L.H.S.).
Background: Fingolimod is an immunomodulatory drug that has shown promising effects in stroke treatment, including improvements in neurofunctional recovery and a reduction in infarct size. Fingolimod modulates the sphingosine-1-phosphate receptors, which leads to the internalization of sphingosine-1-phosphate receptors on T and B lymphocytes, thereby preventing their egress from secondary lymphoid organs. Here, we report a secondary analysis from the Stroke Preclinical Assessment Network trial.
View Article and Find Full Text PDFHealth Place
August 2025
CERA Group, Togo. Electronic address:
There is a substantial unmet need for contraception in West Africa. Providing contraception in private pharmacies, which often are highly accessible, may alleviate some access barriers. However, privacy is a key concern for provision of contraceptives in pharmacies, and whether users view pharmacies as private is ambiguous.
View Article and Find Full Text PDFBiogerontology
August 2025
Tally Health, New York, NY, USA.
A recent publication presented the results of a survey given to longevity experts that attended the 2022 Systems Aging Gordon Research Conference. Corroborating results from a prior survey and broader discussions in the field, the authors found that there was little consensus on fundamental topics, including what causes aging. While this disagreement is not particularly surprising, the spread of answers to the following prompt was unexpected: "The average lifespan in developed countries will be increased by >10 years in the next 20 years.
View Article and Find Full Text PDFNat Immunol
September 2025
Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Liver Transpl
August 2025
Transplant, Baylor All Saints Medical Center at Fort Worth, Transplant, Fort Worth, Texas, USA.