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http://dx.doi.org/10.1093/jac/dkad004 | DOI Listing |
Biomed Chromatogr
October 2025
Department of Pharmaceutical Analysis, Pharmacy School, Shenyang Pharmaceutical University, Shenyang, China.
A rapid and specific liquid chromatography-tandem mass spectrometry method with a wide linear range was developed and validated for the simultaneous quantification of Vitamin K1 (VK1) trans- and cis- isomers in human plasma. Bovine serum albumin solution (15%) served as a surrogate matrix for preparing the calibrators to establish the quantitative curves. After liquid-liquid extraction, VK1 trans- and cis- isomers in plasma samples were separated on a ChromCore C30 column (15 cm × 4.
View Article and Find Full Text PDFMikrochim Acta
September 2025
Pharmaceutical Analysis Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Salmonella Typhimurium (S. Typhimurium) is one of the most common food-borne diseases, highlighted as the top food-borne bacterial pathogen in the world with a low infectious dose (1 CFU) and high mortality rate. It is commonly associated with numerous foods such as dairy products, protein sources (multiple types of meat, poultry, and eggs), and bakery products.
View Article and Find Full Text PDFActa Pharmacol Sin
September 2025
Key Laboratory of Mental Health of the Ministry of Education, Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Guangdong-Hong Kong Joint Laboratory for Psychiatric Disorders, Guangdong Province Key Laboratory of Psychiatric Disorders, Guangdong Bas
Recent investigations into the rapid antidepressant effects of ketamine, along with studies on schizophrenia-related susceptibility genes, have highlighted the GluN2A subunit as a critical regulator of both emotion and cognition. However, the specific impacts of acute pharmacological inhibition of GluN2A-containing NMDA receptors on brain microcircuits and the subsequent behavioral consequences remain poorly understood. In this study, we first examined the effects of MPX-004, a selective GluN2A NMDA receptor inhibitor, on behavior within the dorsomedial prefrontal cortex (dmPFC).
View Article and Find Full Text PDFACS Nano
September 2025
College of Materials Science and Engineering, Fuzhou University, Fuzhou 350108, China.
Polymorphic two-dimensional (2D) transition metal dichalcogenides (TMDCs) exhibit diverse properties for optoelectronic applications. Here, utilizing phase-engineered MoTe as a prototypical platform, we comprehensively explored its ultrafast and nonlinear optical properties to complete the fundamental framework of phase-dependent optical phenomena in 2D TMDCs. Starting with the phase-selective synthesis of 2H- and 1T'-MoTe with tailored thicknesses, we revealed their distinct photocarrier relaxation mechanisms using intensive power-/temperature-/thickness-dependent transient absorption spectra (TAS).
View Article and Find Full Text PDFSci Justice
September 2025
School of Chemistry, University of Leicester, University Road, Leicester LE1 7RH, United Kingdom; Coventry University, School of Science, Coventry CV1 2DS, United Kingdom.
This review explores the geographical distribution of human taphonomy facilities (HTFs) in connection to climate and homicide rates from the 50 most impacted cities worldwide. Existing HTFs depict temperate climates, omitting tropical and arid areas. This underrepresentation impairs accurate post-mortem interval (PMI) estimates and limits the applicability of findings to global contexts.
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