Nickel-Catalyzed Direct Cross-Coupling of Aryl Thioether with Aryl Bromide.

Org Lett

Technical Institute of Fluorochemistry (TIF), Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, China.

Published: March 2023


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Article Abstract

A straightforward cross-coupling of aryl thioether with aryl bromide with the aid of nickel salt, magnesium, and lithium chloride in tetrahydrofuran at ambient temperature was accomplished. The one-pot reactions proceeded efficiently via C-S bond cleavage to produce the desired biaryls in modest to good yields, avoiding the use of pregenerated or commercial organometallic reagents.

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http://dx.doi.org/10.1021/acs.orglett.3c00518DOI Listing

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