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Article Abstract
Background: It has been reported that ING3 inhibits the progression of various cancers. However, some studies have shown that it promotes the development of prostate cancer. The purpose of this study was to investigate whether ING3 expression is associated with the prognosis of patients with cancer.
Materials And Methods: PubMed, Cochrane Database, Embase, Medline, ScienceDirect, Scopus and Web of Science were searched until September 2022. The hazard ratio (HR)/odds ratio (OR) and 95% confidence interval (95% CI) were calculated using Stata 17 software. We used the Newcastle-Ottawa Scale (NOS) to assess the risk of bias.
Result: Seven studies involving 2371 patients with five types of cancer were included. The results showed that high expression of ING3 was negatively associated with a more advanced TNM stage (III-IV vs. I-II) (OR=0.61, 95% CI: 0.43-0.86), lymph node metastasis (OR=0.67, 95% CI: 0.49-0.90) and disease-free survival (HR=0.63, 95% CI: 0.37-0.88). However, ING3 expression was not associated with overall survival (HR=0.77, 95% CI: 0.41-1.12), tumor size (OR=0.67, 95% CI: 0.33-1.37), tumor differentiation (OR=0.86, 95% CI: 0.36-2.09) and gender (OR=1.14, 95% CI: 0.78-1.66).
Conclusion: This study showed that the expression of ING3 was associated with better prognosis, suggesting that ING3 may be a potential biomarker for cancer prognosis.
Systematic Review Registration: https://www.crd.york.ac.uk/prospero/, identifier (CRD42022306354).
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9948604 | PMC |
| http://dx.doi.org/10.3389/fonc.2023.1090860 | DOI Listing |
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Article Synopsis
- Chemoresistance in colorectal cancer (CRC) complicates treatment, and this study focuses on the role of MDM2, a ubiquitin E3 ligase, in influencing CRC cell growth and response to chemotherapy.
- Researchers analyzed the interaction between MDM2 and the transcription factor ING3, discovering that MDM2 reduces ING3 protein stability through a process called ubiquitination, which leads to increased cell proliferation and decreased apoptosis in CRC cells.
- The study also confirms, through experiments in mice, that the combined effects of MDM2 and reduced ING3 expression contribute to tumor growth and chemoresistance in colorectal cancer.