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Objective: Endoscopic transnasal approaches (ETAs) to the ventrolateral skull base are commonly classified according to coronal planes or anatomical structures. Our goal is to simplify the description of the ETA to lateral skull base regions in a sequential dissection with correlation to computed tomography, helping in preoperative planning and efficient surgical exposure, and exposing the surgical anatomy limitations.
Methods: Five freshly injected cadaver heads were dissected using an extended ETA to the lateral skull base. Each specimen underwent a high-resolution computed tomography scan. A classification of the lateral skull base based on well-defined zones was proposed.
Results: We divided the lateral target into four different zones, in a craniocaudal orientation: zone 1 is the space lying between the orbital floor superior and the level of the sellar floor inferior, zone 2 is on the coronal plane, located between the level of the sellar floor and the vidian canal, zone 3 is the area lateral to the anterior limb of the petro-occipital fissure, located between the vidian canal and the carotid canal, and zone 4 is the space located between the carotid canal and the extracranial opening of the hypoglossal canal, lateral to the anterior part of the posterior limb of petro-occipital fissure.
Conclusions: Multiple previous works have described and classified the coronal plane and its lateral extensions. Our classification system for the proposed lateral zones enables preoperative planning to select a suitable approach. The craniocaudal orientation facilitates the understanding of surgical corridors and tailored exposure.
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http://dx.doi.org/10.1016/j.wneu.2023.02.093 | DOI Listing |
World Neurosurg
September 2025
Department of Neurosurgery, Bahcesehir Universty School of Medicine, Istanbul, Turkey. Electronic address:
Background And Objectives: The endoscopic endonasal approach (EEA) has become a key surgical method for managing midline skull base lesions, offering minimally invasive access with reduced morbidity. One of the most significant complications following EEA is cerebrospinal fluid (CSF) leakage, especially in high-flow cases. Based on over two decades of institutional experience with 6,221 EEA procedures, this study aims to categorize and evaluate standardized reconstruction strategies based on intraoperative CSF flow rates in order to optimize outcomes and reduce postoperative complications.
View Article and Find Full Text PDFRhinology
September 2025
Department of Otorhinolaryngology-Head and Neck Surgery, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, China.
Skull base reconstruction is a critical component of endoscopic endonasal skull base surgery (EESBS). Bed rest remains an indispensable element of post-operative care, which should be carefully considered for reducing the risk of cerebrospinal fluid (CSF) leaks and enhancing surgical outcomes (1, 2). However, the necessity of bed rest continues to be controversial as indicated by the expert consensus on perioperative management of skull base reconstruction, due to a lack of high-quality evidence to support its effectiveness (1-4).
View Article and Find Full Text PDFRhinology
September 2025
Allergy and Clinical Immunology Research Group, Department of Microbiology, Immunology and Transplantation, KU Leuven, Belgium.
Background: Criteria for biologic treatment of uncontrolled severe chronic rhinosinusitis with nasal polyps (CRSwNP) differ across international recommendations and prescription of biologics depends on national reimbursement criteria. CHRINOSOR offers an opportunity to analyse biologic indications in the real-world setting according to international recommendations.
Methods: CRSwNP patients who received dupilumab treatment in the ENT clinic of 6 tertiary centres (5 countries) were included.
Biomater Biosyst
September 2025
ENT and Head and Neck Research Center and Department, The Five Senses Health Institute, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Introduction: The airway mucosa plays a crucial role in protection and various physiological functions. Current methods for restoring airway mucosa, such as myocutaneous flaps or split skin grafts, create a stratified squamous layer that lacks the cilia and mucus-secreting glands of the native columnar-lined airway. This study examines the application of various injectable biopolymers as active molecules for a potential approach to regenerating laryngeal epithelial tissue.
View Article and Find Full Text PDFPhys Imaging Radiat Oncol
July 2025
Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milan, Italy.
Biology-guided voxel-level inverse prescription mapping for dose painting (DP) using diffusion-weighted magnetic resonance imaging was evaluated for technical feasibility in proton therapy for 10 skull-base chordoma patients. Patient-specific DP prescriptions were generated from tumour cellularity and implemented in a clinical treatment planning system. Compared with uniform plans, DP achieved lower conformity (although >97 %), improved target dose metrics, reduced doses to most organs at risk, and increased tumour control probability without exceeding clinical constraints.
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