Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Introduction: Common carotid intima-media thickness (cIMT) is a marker of subclinical atherosclerosis and is associated with cognitive decline. Although carotid atherosclerosis is more frequent in White than in Black participants, little is known whether race modifies the association between cIMT and cognitive decline.
Methods: In this longitudinal analysis of the ELSA-Brasil, we assessed cIMT using ultrasound and cognitive performance using different domain tests. We used linear mixed models, interaction analysis, and race stratified analyses.
Results: Baseline high IMT values were associated with memory (p < 0.001), verbal fluency (p < 0.001), TMT-B (p < 0.001)), and global cognitive decline (p < 0.001). Race was an effect modifier in the association between IMT and global cognitive decline (0.043), with stronger association in White (p < 0.001) than in Black (p = 0.009) participants.
Discussion: Baseline IMT was associated with global and domain-specific cognitive decline and race modified this relationship, with stronger associations in White participants.
Highlights: Carotid intima-media thickness (cIMT) was associated with cognitive decline. cIMT and cognitive decline association was stronger in White than in Black participants. We used inverse probability weighting to address attrition bias.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/alz.12996 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Association Between the Vascular Ageing of the Carotid Arteries and Different Dialysis Modalities.
Cureus
August 2025
Center for Clinical Pharmacology, Medical Faculty of Military Medical Academy, Belgrade, SRB.
Background Chronic kidney disease is a major global health problem, significantly increasing the risk of cardiovascular complications compared to the general population. This study aimed to evaluate vascular aging in patients with end-stage renal disease treated with hemodialysis or peritoneal dialysis by analyzing clinical and laboratory parameters and carotid intima-media thickness (CIMT), with the goal of identifying predictors of carotid disease and comparing the prevalence between groups. Methods We conducted a retrospective cohort study that included 59 subjects with end-stage renal disease who were treated with renal replacement therapy: peritoneal dialysis (29 subjects) and hemodialysis (30 subjects).
View Article and Find Full Text PDFThe Association of Premature Atherosclerosis with Ischemic Stroke in Young People with HIV in Lusaka, Zambia.
J Stroke Cerebrovasc Dis
September 2025
Department of Internal Medicine, University Teaching Hospital, Lusaka, Zambia; Department of Internal Medicine, University of Zambia School of Medicine, Lusaka, Zambia; Department of Neurology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
Background: Premature atherosclerosis has been observed among people with HIV (PWH) with high risk of cerebrovascular disease. The aim of this study was to evaluate premature atherosclerosis in young PWH with and without ischemic stroke.
Methods: We conducted a prospective case-control study at the University Teaching Hospital in Lusaka, Zambia between March 2022 and October 2024, comparing young PWH with non-cardioembolic ischemic stroke (cases) with PWH without a history of stroke (controls) matched (1:2) for age, sex and race.
Rotating shift work, with night shift work, affects cardiovascular risk factors: a 6-year follow-up study in the insulation industry.
Occup Environ Med
September 2025
Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway.
Objectives: To assess absolute levels and longitudinal changes in cardiovascular disease (CVD) risk factors over 6 years among rotating shift workers with night shift work and day workers in industry.
Methods: We studied three groups, 32 night shift workers in Plant A with a high night load, 23 in Plant B with a low night load and 25 day workers during a 6-year follow-up (FU). We collected demographics by questionnaire, measured blood pressure, resting heart rate, carotid intima-media thickness (cIMT), carotid to femoral pulse wave velocity (cfPWV) and maximal oxygen uptake (V̇O).
Association of polycystic ovary syndrome with atherosclerotic cardiovascular disease events.
Fertil Steril
September 2025
Dept of OBGYN, University of Rochester, Rochester, NY, USA. Electronic address:
Polycystic ovary syndrome (PCOS) is a common endocrine condition often recognized for its association with reproductive complications. However, the impact of PCOS extends well beyond such that it is considered a multisystemic disorder, with effects on mental health, metabolic conditions, and pregnancy. While there is ample evidence for increased prevalence of cardiovascular disease (CVD) risk factors in PCOS including hypertension, dyslipidemia, diabetes and obesity in reproductive age and menopausal women, robust data on atherosclerotic CVD events (ASCVD), defined as coronary artery disease (CAD), myocardial infarction (MI), angina, carotid artery disease, ischemic stroke, transient ischemic attack (TIA) and peripheral artery disease (PAD), in PCOS is emerging.
View Article and Find Full Text PDFLongitudinal Association of Peak Oxygen Uptake with Vascular and Cardiac Structure and Function in German Paediatric Athletes.
Am J Physiol Heart Circ Physiol
September 2025
Institute of Public Health and Clinical Nutrition, School of Medicine, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.
This study aims to investigate the longitudinal associations between changes in maximal cardiorespiratory fitness (CRF) and vascular/cardiac structure and function in paediatric athletes. 142 paediatric athletes with data for baseline and a one-year follow-up from the Munich Cardiovascular Adaptation in Young Athletes (MuCAYA) study (mean [SD] age at baseline: 14.0 [2.
View Article and Find Full Text PDF