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http://dx.doi.org/10.1001/jamaoncol.2022.7770 | DOI Listing |
Haematologica
September 2025
Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD,.
Immunotherapies, including cell therapies, are effective anti-cancer agents. However, cellular product persistence can be limiting with short functional duration of activity contributing to disease relapse. A variety of manufacturing protocols are used to generate therapeutic engineered T-cells; these differ in techniques used for T-cell isolation, activation, genetic modification, and other methodology.
View Article and Find Full Text PDFInfect Control Hosp Epidemiol
September 2025
Division of Pediatric Infectious Diseases, Department of Pediatrics, Monroe Carell Jr. Children's Hospital, Vanderbilt University Medical Center, Nashville, TN, USA.
Objective: In the and genes have been associated with elevated MICs to antiseptics with such organisms often termed antiseptic tolerant (ATSA). The impact of repeated healthcare or antiseptic exposure on colonization with ATSA is uncertain.
Design: Prospective longitudinal cohort study.
Toxicol Mech Methods
September 2025
Laboratory of Mutagenesis, Institute of Biological Sciences (ICB I), Federal University of Goias, Goiania, Goias, Brazil.
While agriculture is essential for food security, the intensive use of pesticides in modern farming practices raises concerns on their impact, in particular from a One Health perspective. In 2024, Brazil approved 663 new pesticides, a 19% increase in comparison with 2023. The occupational exposure of rural workers is known to be associated with a range of health outcomes, including cancer.
View Article and Find Full Text PDFArch Pharm (Weinheim)
September 2025
Department of Biology, Faculty of Arts and Sciences, Cukurova University, Adana, Turkey.
l-Ascorbic acid exhibits paradoxical behavior as both antioxidant and pro-oxidant in cancer treatment, with mechanisms and optimal dosing remaining unclear. This in vitro study investigated l-ascorbic acid's effects on healthy lymphocytes and HL-60 leukemia cells using concentrations of 0.5-2 mg/mL for 6 and 24 h.
View Article and Find Full Text PDFGeroscience
September 2025
Department of Urology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
This study aims to investigate the predictive value of combined phenotypic age and phenotypic age acceleration (PhenoAgeAccel) for benign prostatic hyperplasia (BPH) and develop a machine learning-based risk prediction model to inform precision prevention and clinical management strategies. The study analyzed data from 784 male participants in the US National Health and Nutrition Examination Survey (NHANES, 2001-2008). Phenotypic age was derived from chronological age and nine serum biomarkers.
View Article and Find Full Text PDF