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| http://dx.doi.org/10.1016/j.jhep.2023.02.008 | DOI Listing |
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Background: Hepatitis E virus (HEV) is a zoonotic pathogen mainly transmitted through contaminated food or water in sub-Saharan countries, highlighting the need for environmental surveillance. This study aimed to assess the burden and molecular characterization of HEV in environmental wastewater.
Method: A community-based surveillance was conducted in Yaoundé, Cameroon, using untreated wastewater samples collected monthly from January to December 2023 from hospitals, residential sewage systems, markets, and plant watering points.
Identification of novel rodent and shrew orthohepeviruses sheds light on hepatitis E virus evolution.
Zool Res
January 2025
Institute of Preventive Medicine, School of Public Health, Dali University, Yunnan Key Laboratory of Screening and Research on Anti-pathogenic Plant Resources from Western Yunnan, Yunnan Key Laboratory of Zoonotic Disease Cross-border Prevention and Quarantine, Dali, Yunnan 671000, China. E-mail: zh
The family has seen an explosive expansion in its host range in recent years, yet the evolutionary trajectory of this zoonotic pathogen remains largely unknown. The emergence of rat hepatitis E virus (HEV) has introduced a new public health threat due to its potential for zoonotic transmission. This study investigated 2 464 wild small mammals spanning four animal orders, eight families, 21 genera, and 37 species in Yunnan Province, China.
View Article and Find Full Text PDFMolecular epidemiology of Hepatitis E virus among humans in the Niger Republic, 2017-2023.
J Clin Virol
February 2025
Virology department, Institut Pasteur de Dakar, 36. Avenue Pasteur Dakar, Dakar 220, Senegal.
Hepatitis E virus (HEV) is the most common cause of acute viral hepatitis, responsible for large outbreaks in resource limited countries. The virus belongs to the genus Orthohepevirus which is subdivided into eight distinct genotypes (HEV-1 to HEV-8). Human disease transmission is mostly through the faecal-oral route.
View Article and Find Full Text PDFZika virus replication is impaired by a selective agonist of the TRPML2 ion channel.
Antiviral Res
August 2024
Department of Virology, Paul-Ehrlich-Institut, 63225, Langen, Germany. Electronic address:
The flavivirus genus includes human pathogenic viruses such as Dengue (DENV), West Nile (WNV) and Zika virus (ZIKV) posing a global health threat due to limited treatment options. Host ion channels are crucial for various viral life cycle stages, but their potential as targets for antivirals is often not fully realized due to the lack of selective modulators. Here, we observe that treatment with ML2-SA1, an agonist for the human endolysosomal cation channel TRPML2, impairs ZIKV replication.
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