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Background: The SARS-CoV-2 (COVID-19) pandemic has dramatically disrupted orthopaedic surgery practice patterns. This study aimed to examine differences between patients who underwent total joint arthroplasty (TJA) before the pandemic compared to 2020 and 2021.
Methods: A retrospective cohort study was performed on all patients who underwent elective inpatient TJA from January 2017 to December 2021 using a national large database. Descriptive statistics were utilized to trend length of stay (LOS) and patient age. Patient demographics, discharge destinations, and rates of medical comorbidities were assessed for patients undergoing TJA in 2020 and 2021 compared to patients from prepandemic years (2017 to 2019). Overall, 1,173,366 TJAs were identified (2017 to 2019: 810,268 TJAs, average 270,089 cases/year; 2020: 175,185 TJAs; 2021: 187,627 TJAs). There was a 35.3% and 30.5% decrease in 2020 and 2021, respectively, when compared to the prepandemic annual average.
Results: Average LOS decreased from 1.6 days in January 2020 to 0.9 days by December 2021. Same-day discharges increased from 6.2% of cases in 2019 to 30.5% in 2021. Discharge to skilled nursing facilities (SNF) reduced from 11.3% in 2017 to 2019 to 4.3% and 4.5% in 2020 and 2021, respectively. Patients ≥70 years old undergoing elective TJA decreased from 39.6% in 2017 to 2019 to 29.2% in April 2020.
Conclusion: In response to the COVID-19 pandemic, same-day discharges following primary elective TJA increased markedly, the average LOS decreased, discharges to SNFs decreased, and a preferential shift toward younger patients was observed.
Level Of Evidence: Therapeutic Level III.
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http://dx.doi.org/10.1016/j.arth.2023.01.048 | DOI Listing |
Background: People with opioid use disorder (OUD) often exhibit high rates of nonprescribed drug use and low retention on buprenorphine. This study tested the feasibility, acceptability, and preliminary efficacy of an intervention combining peer recovery coaching and CBT4CBT-buprenorphine (CBT4CBT+RC) to reduce nonprescribed drug use and increase buprenorphine retention.
Methods: A randomized trial conducted from December 15, 2020, to November 24, 2021, compared an 8-week CBT4CBT+RC intervention to treatment as usual (TAU).
Vet Med Sci
September 2025
Department of Pharmacology and Toxicology, Faculty of Veterinary, Animal and Biomedical Sciences, Sylhet Agricultural University, Sylhet, Bangladesh.
The emergence of antimicrobial resistance (AMR) Escherichia coli in poultry farming is a growing global public health concern, particularly in Bangladesh, where the use of antibiotics remains largely unregulated. This study aimed to determine the prevalence and AMR patterns of E. coli isolated from broiler chickens in Sylhet district of Bangladesh and to investigate the network of coexisting resistance traits among the isolates.
View Article and Find Full Text PDFChild Psychiatry Hum Dev
September 2025
School of Psychology, Deakin University, 221 Burwood Highway, Burwood, VIC, 3125, Australia.
The COVID-19 pandemic presented a unique opportunity to investigate the longitudinal associations between parents' pre-pandemic mental health issues and their emotion-related parenting practices during the pandemic, as well as the impact on children's socio-emotional functioning. The present study aimed to: 1) investigate associations between pre-existing parent mental health issues (2019) with children's long-term socio-emotional functioning (2021), via changes in emotion-related parenting practices during the COVID-19 pandemic (2020); and 2) test whether COVID-19 pandemic-related environmental stressors during 2020 and 2021 exacerbated associations between emotion-related parenting practices and children's socio-emotional functioning. Data were drawn from the Child and Parent Emotion Study (CAPES).
View Article and Find Full Text PDFMol Biol Rep
September 2025
Dr. B. R. Ambedkar Centre for Biomedical Research North Campus , University of Delhi, 110007, Delhi, India.
Background: Standard treatment for glioblastoma includes chemotherapy, alkylating agents such as temozolomide (TMZ); however, MGMT resistance leads to recurrence. Demethoxycurcumin (DMC) has been reported to inhibit cancer cell growth, induce apoptosis, and prevent metastasis in different cancer models. We investigated the DMC-induced apoptosis and autophagy via inhibition of the AKT/mTOR pathway in human glioma U87MG and T98G cell lines.
View Article and Find Full Text PDFEnviron Monit Assess
September 2025
Institute of Environmental Studies, Kurukshetra University, Kurukshetra, Haryana, 136119, India.
India produces an estimated 6.38 million tons of surplus sugarcane trash annually. When burned in fields, this trash emits approximately 12,948 kg CO equivalent greenhouse gases per hectare and causes nutrient losses (41 kg ha nitrogen, 5.
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