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This work proposes a novel design composed of graphene nanoribbons-based optofluidic tweezers to manipulate and sort bio-particles with radii below 2.5 nm. The suggested structure has been numerically investigated by the finite difference time domain (FDTD) method employing Maxwell's stress tensor analysis (MST). The finite element method (FEM) has been used to obtain the electrostatic response of the proposed structure. The tweezer main path is a primary channel in the center of the structure, where the microfluidic flow translates the nanoparticle toward this channel. Concerning the microfluid's drag force, the nanoparticles tend to move along the length of the main channel. The graphene nanoribbons are fixed near the main channel at different distances to exert optical forces on the moving nanoparticles in the perpendicular direction. In this regard, sub-channels embedding in the hBN layer on the Si substrate deviate bio-particles from the main path for particular nanoparticle sizes and indices. Intense hotspots with electric field enhancements up to 900 times larger than the incident light are realized inside and around the graphene ribbons. Adjusting the gap distance between the graphene nanoribbon and the main channel allows us to separate the individual particle with a specific size from others, thus guiding that in the desired sub-channel. Furthermore, we demonstrated that in a structure with a large gap between channels, particles experience weak field intensity, leading to a low optical force that is insufficient to detect, trap, and manipulate nanoparticles. By varying the chemical potential of graphene associated with the electric field intensity variations in the graphene ribbons, we realized tunability in sorting nanoparticles while structural parameters remained constant. In fact, by adjusting the graphene Fermi level via the applied gate voltage, nanoparticles with any desired radius will be quickly sorted. Moreover, we exhibited that the proposed structure could sort nanoparticles based on their refractive indices. Therefore, the given optofluidic tweezer can easily detect bio-particles, such as cancer cells and viruses of tiny size.
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http://dx.doi.org/10.1038/s41598-023-29122-w | DOI Listing |
Trans R Soc Trop Med Hyg
September 2025
Institut Pasteur, Université de Paris Cité, CNRS UMR 3569, Virus sensing and signaling Unit, 75015 Paris, France.
Background: In 2023, Mayotte, a French department in the Mozambique channel, experienced a long drought that led to potable water restrictions. Although the French vaccination schedule makes polio vaccination compulsory for children, the large proportion of migrants on the island coupled with the water crisis raised concerns about the establishment of poliovirus transmission chains. Therefore, a surveillance was implemented to detect polioviruses in sewage sampled in the two main wastewater treatment plants.
View Article and Find Full Text PDFPestic Biochem Physiol
November 2025
Université Côte d'Azur, INRAE, CNRS, ISA, Sophia Antipolis, France. Electronic address:
Spodoptera frugiperda is a major crop pest that invaded Thailand in 2018 which cause significant damage, particularly to maize. In recent years, a loss of efficacy of certain insecticides has been observed, suggesting the emergence of resistance. The aim of our study was to investigate the molecular mechanisms of resistance in S.
View Article and Find Full Text PDFProg Biophys Mol Biol
September 2025
Grupo de investigación en Química Teórica y Bioinformática, Department of Chemistry, Universidad de Caldas, Cl. 65 # 26-10, Manizales, Colombia.
The primary objective of this review is to analyze primary research published over the past six years concerning cyclic nucleotide-gated calcium channels (CNGC) in plants. The aim is to structure this information to identify and organize existing knowledge regarding their tertiary and quaternary structures, as well as the activation mechanisms of CNGC. Studies on plant CNGC published between January 2018 and May 2025 were included, while research focused on animals, bacteria, or ions other than calcium was excluded.
View Article and Find Full Text PDFSoft Matter
September 2025
Department of Mechanical Engineering, Clemson University, Clemson, SC 29634-0905, USA.
Pores scale flows through contractions and expansions are relevant in geoengineering, microfluidics and material processing These flows experience shearing and extensional kinematics near constrictions, where polymer solutions may demonstrate instabilities that arise from the fluid's nonlinear rheological characteristics even in creeping flows. The relative effect of shearing and extension can be controlled by the flow geometry. Following our earlier reports on the constriction length (M.
View Article and Find Full Text PDFFront Public Health
September 2025
Graduate School of Advanced Integrated Studies in Human Survivability, Kyoto University, Kyoto, Japan.
Objectives: As environmental pollution and population aging become increasingly severe, it is especially important to assess the health co-benefits of climate-related urban policies. This study aims to examine the impact of China's Low-Carbon City Pilot Program (LCCP) on the health of the older adults. It focuses on potential mechanisms such as improvements in environmental quality and increases in non-motorized transportation.
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