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Colorectal adenocarcinoma (CRC) most commonly metastasizes to the peritoneum, liver, lung, and bone. Metastasis to the oral cavity is uncommon. Here, we report the case of a 74-year-old man who presented with a few months of chewing and swallowing difficulty, shoulder pain, and weight loss of 30 pounds. On oral exam, he was noted to have a 5 cm fixed hard palate mass. Primary hard palate malignancy was initially suspected. Biopsy of the mass confirmed adenocarcinoma with an immunohistochemical pattern suggestive of colorectal origin. He was later found to have extensive skeletal metastasis. Palliative radiotherapy to the hard palate region was initiated, followed by palliative systemic chemotherapy. We have found only three other published cases of rectal adenocarcinoma with hard palate metastasis.
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http://dx.doi.org/10.7759/cureus.33082 | DOI Listing |
J Texture Stud
October 2025
College of Automation Engineering, Northeast Electric Power University, Jilin, China.
Astringency is a complex oral sensation characterized by dryness and constriction in the mouth. It is typically induced by polyphenol-rich foods and beverages such as wine and tea. The quantitative assessment of astringency intensity has become a prominent research focus in the food science field.
View Article and Find Full Text PDFJ Small Anim Pract
September 2025
Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, Prince Edward Island, Canada.
A 12-year-old castrated male golden retriever was referred for evaluation of a palatal mass. Computed tomography identified a 2.7 × 2.
View Article and Find Full Text PDFJ Med Cases
August 2025
Internal Medicine Department, Unidade Local de Saude de Sao Joao, Alameda Professor Hernani Monteiro, 4200-319 Porto, Portugal.
Methotrexate is a commonly prescribed immunosuppressant and chemotherapy agent, carefully monitored by healthcare providers due to its potential adverse effects. As a result, methotrexate toxicity is relatively rare. We present the case of a 79-year-old man followed in rheumatology for symmetrical polyarthralgia, who inadvertently took methotrexate 10 mg daily, instead of weekly, leading to methotrexate toxicity.
View Article and Find Full Text PDFStomatologiia (Mosk)
September 2025
Central Research Institute of Dentistry and Maxillofacial Surgery, Moscow, Russia.
Objective: Improving the effectiveness of primary surgery of uranoplasty and re-reconstruction of the palate in patients with cleft palate through the use of an axial flap of the fat body of the cheek.
Material And Methods: In the period from 2023-2024, 41 patients with cleft palate aged from 1 to 19 years were operated on. Of these, 28 people had a flap of the cheek fat body used in risk groups during primary uranoplasty (group 1) and in 13 patients to eliminate postoperative palate defects of various localization and extent (group 2).
Arch Craniofac Surg
August 2025
Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Background: The pre-lacrimal window (PLW) approach is a promising technique for accessing otherwise inaccessible maxillary sinus lesions. The objective of this study was to determine the computed tomography (CT) dimensions, measurements, and grading of the PLW.
Methods: One hundred paranasal CT scans were included in the study.