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http://dx.doi.org/10.1182/blood.2022018896 | DOI Listing |
BMC Plant Biol
September 2025
Department of Botany and Microbiology, Faculty of Science, South Valley University, Qena, 83523, Egypt.
Background: Apples are important for human nutrition because these provide vital nutrients, including vitamins and minerals, that are needed for a balanced diet. A suitable environment for the growth and survival of various microorganisms is also provided by multiple nutrients, such as carbohydrates, minerals, vitamins, and amino acids. Penicillium spp.
View Article and Find Full Text PDFPharm Res
September 2025
Axcelead Tokyo West Partners, Inc. Translational Science, Discovery DMPK, Hino-Shi, Tokyo, 191-0065, Japan.
Purpose: Accurate prediction of human clearance (CL) is essential in early drug development. Single Species Scaling (SSS) using rat pharmacokinetic (PK) data, particularly with unbound plasma fraction (f), is widely used. However, its accuracy declines for compounds with extremely low f, and no systematic method has addressed this limitation.
View Article and Find Full Text PDFMol Syst Biol
September 2025
Centre for Individualised Infection Medicine (CiiM), a joint venture between the Helmholtz Centre for Infection Research (HZI) and Hannover Medical School (MHH), Hannover, Germany.
The complex interplay between circulating metabolites and immune responses, which is pivotal to disease pathophysiology, remains poorly understood and understudied in systematic research. Here, we performed a comprehensive analysis of the immune response and circulating metabolome in two Western European cohorts (534 and 324 healthy individuals) and one from sub-Saharan Africa (323 healthy donors). At the metabolic level, our analysis revealed sex-specific differences in the correlation between phosphatidylcholine and cytokine responses following ex vivo stimulation.
View Article and Find Full Text PDFNat Rev Urol
September 2025
Department of Genitourinary Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Low-grade non-muscle invasive bladder cancer is a specific category of bladder cancer with a favourable prognosis; however, its management presents several challenges. The risk of stage progression is very low, but approximately half of patients will experience recurrence within the first 5 years after diagnosis. This high propensity for recurrence, coupled with the threat of progression, mandates ongoing surveillance.
View Article and Find Full Text PDFNature
September 2025
Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Small cell lung cancer (SCLC) is a highly aggressive type of lung cancer, characterized by rapid proliferation, early metastatic spread, frequent early relapse and a high mortality rate. Recent evidence has suggested that innervation has an important role in the development and progression of several types of cancer. Cancer-to-neuron synapses have been reported in gliomas, but whether peripheral tumours can form such structures is unknown.
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