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http://dx.doi.org/10.1016/j.jid.2023.01.009 | DOI Listing |
Oncoimmunology
December 2025
Department for Cell and Gene Therapy Development, Fraunhofer Institute for Cell Therapy and Immunology (IZI), Leipzig, Germany.
CAR-based cell therapies have shown clinical success in treating various cancers, with CAR T cell therapies entering the clinical route and CAR NK cell therapies being evaluated in early-stage clinical trials. A key challenge is the presence of tumor-associated antigens on healthy cells, risking on-target off-tumor toxicities. Our comparative analysis of CAR T and CAR NK cells targeting the multiple myeloma-associated antigens BCMA, SLAMF7, and CD38 revealed that antigen density on target cells significantly modulates CAR NK cell activation and cytotoxicity.
View Article and Find Full Text PDFCoronary artery disease (CAD), tuberculosis (TB), and HIV represent major global health burdens. Individuals affected by one or more of these conditions often exhibit chronic inflammation and immune dysregulation, with monocytes playing a central role in these processes. Monocyte subsets are known to expand in individuals with HIV, TB, or CAD.
View Article and Find Full Text PDFRinsho Ketsueki
September 2025
Department of Hematology, Kawasaki Medical School.
Warm autoimmune hemolytic anemia (wAIHA) is an autoimmune disorder in which autoantibodies target the patient's own red blood cells. It can be classified as either idiopathic (primary) or secondary and is characterized by the presence of pan-reactive immunoglobulin G (IgG) autoantibodies that recognize epitopes on erythrocyte membrane proteins such as band 3 and Rh polypeptides. Spontaneous remission is rare, and corticosteroids are commonly used as first-line therapy.
View Article and Find Full Text PDFOnco Targets Ther
August 2025
Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Although recent decades have seen continued improvements in survival for patients with multiple myeloma, the disease remains largely incurable, and most patients will experience relapse and/or become refractory to treatment. There thus remains an urgent unmet need for novel treatments, particularly for those patients with relapsed or refractory multiple myeloma. Novel treatment modalities, such as targeted protein degradation, have attracted particular interest due to their ability to expand the range of druggable protein targets in myeloma cells.
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