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Introduction: Bone consolidation defects represent a real orthopedic challenge because of the absence of validated treatment guidelines that can assist the surgeon in his choices. The aim of this study is to evaluate the appropriateness of the Non-Union Scoring System NUSS treatment protocol in the management of long bone non-unions by comparing it to the experience-based therapeutic approach carried out in our facility.
Materials And Methods: We conducted a comparative outcome study of a retrospective series of 89 patients surgically treated for long bone non-union in our facility vs. clinical results reported by Calori et al. obtained following the NUSS treatment protocol.
Results: Radiographic healing was reached in 13/13 non-unions (100%) in group NUSS 1, in 58/62 (93.5%) in group NUSS 2, and in 13/14 (92.9%) in group NUSS 3. The mean time to radiographic healing was 5.69 ± 2.09 months in group 1, 7.38 ± 3.81 months in group 2 and 9.23 ± 2.31 months in group 3. 91% of patients in group I, 69% in group II and 48% in group III received what would be considered by the NUSS treatment protocol an "overtreatment", especially from a biological stand point. The comparative outcome analysis shows that our case series achieved significantly higher global healing rates ( value = 0.017) and shorter radiological healing times in groups NUSS 1 and 2 ( value < 0.001).
Conclusion: From the results obtained, we can assume that the NUSS treatment protocol might underestimate the necessary therapies, particularly from a biological point of view.
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http://dx.doi.org/10.1007/s43465-022-00767-5 | DOI Listing |
Pain Res Manag
September 2025
Department of Thoracic and Cardiovascular Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Pectus excavatum is a common congenital chest wall deformity that can lead to significant cardiopulmonary compression and psychological distress. The minimally invasive Nuss procedure is the standard treatment, but it often results in severe postoperative pain. Effective perioperative pain management is essential to enhance recovery and improve patient outcomes.
View Article and Find Full Text PDFJAMA Pediatr
September 2025
Department of Pediatrics, Nemours Children's Health, Wilmington, Delaware.
Importance: Guidelines for the timely emergency department (ED) administration of opioids for acute sickle cell disease (SCD) pain lack clear evidence showing associations with reduced hospitalizations.
Objective: To evaluate the associations between the timely administration of multiple opioid doses during uncomplicated SCD pain episodes in children and hospitalization.
Design, Setting, And Participants: This multisite cross-sectional study used data from the Pediatric Emergency Care Applied Research Network Registry.
J Pediatr Surg
August 2025
Division of Pediatric Surgery, Department of Surgery, Phoenix Children's, Phoenix, AZ, USA; Department of Child Health and Development, University of Arizona, School of Medicine, Phoenix, AZ, USA. Electronic address:
Purpose: Gabapentin is used for treating postoperative pain and preventing neuropathic pain. We aimed to examine the effects of gabapentin on opioid use and neuropathic pain following minimally invasive repair of pectus excavatum with intercostal nerve cryoablation (MIRPE-INC).
Methods: A prospective comparison study was conducted among patients ≤21 years old undergoing MIRPE-ICN.
ACS Chem Neurosci
August 2025
Univ. Bordeaux, CNRS, Bordeaux INP, CBMN, UMR 5248, F-33600 Pessac, France.
Antipsychotics (APs) are used in the treatment of severe mental disorders. Their mechanism of action involves interaction with multiple brain targets, notably the dopamine D2 receptor (D2R), where they compete with dopamine. Due to their lipophilic nature, APs also partition and accumulate in lipid membranes, particularly around the D2R and in synaptic vesicles.
View Article and Find Full Text PDFJ Clin Anesth
September 2025
Department of Anesthesiology, the Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, China. Electronic address:
Study Objective: Minimally invasive repair of pectus excavatum (Nuss procedure) is associated with significant postoperative pain and high-dose opioid consumption. Liposomal bupivacaine (LB), as an ultra-long-acting local anesthetic, has been extensively studied for perioperative analgesia. However, data regarding the effects of LB on postoperative pain in children undergoing the Nuss procedure remain limited.
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