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http://dx.doi.org/10.1007/s13760-023-02186-1 | DOI Listing |
Brain
September 2025
Aix Marseille Univ, INSERM, INS, Inst Neurosci Syst, 13005 Marseille, France.
The lateral prefrontal cortex (LPFC) serves as a critical hub for higher-order cognitive and executive functions in the human brain, coordinating brain networks whose disruption has been implicated in many neurological and psychiatric disorders. While transcranial brain stimulation treatments often target the LPFC, our current understanding of connectivity profiles guiding these interventions based on electrophysiology remains limited. Here, we present a high-resolution probabilistic map of bidirectional effective connectivity between the LPFC and widespread cortical and subcortical regions.
View Article and Find Full Text PDFJCI Insight
September 2025
Department of Pharmacology, University of Michigan, Ann Arbor, United States of America.
Cardiac hypertrophy is a common adaptation to cardiovascular stress and often a prelude to heart failure. We examined how S-palmitoylation of the small GTPase, Ras-related C3 botulinum toxin substrate 1 (Rac1), impacts cardiomyocyte stress signaling. Mutation of the cysteine-178 palmitoylation site impaired activation of Rac1 when overexpressed in cardiomyocytes.
View Article and Find Full Text PDFPsychol Res
September 2025
Berlin School of Mind and Brain & Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.
The existence of free will has been called into question by Benjamin Libet's seminal experiment, who argued that our conscious decision is preceded by an unconscious decision reflected in the readiness potential (RP). Alternatively, it has been argue that the RP rather reflects a decision process in which different signals accumulate until they reach the intention threshold, at which point an agent experience their intention simultaneously. This raises the question what type of signal is accumulated given that no external information is provided.
View Article and Find Full Text PDFBrain Behav
September 2025
Department of Physical Therapy, Niigata University of Health and Welfare, Niigata, Japan.
Introduction: We aimed to clarify the effects of an active touch intervention using different textures on corticospinal excitability.
Methods: A total of 30 healthy individuals participated in the active touch intervention. Two tactile stimuli were used for intervention: smooth (silk) and rough (hessian) stimuli.
Cogn Neurodyn
December 2025
School of Mathematics, Northwest University, Xi'an, China.
This study sought to enhance visual acuity assessment using steady-state visual evoked potentials (SSVEPs) through subject-specific training methods. SSVEPs were elicited from eleven subjects using the vertical sinusoidal gratings at six various spatial frequency steps, and then the classical approach of Oz single-channel, the spatial filtering method of canonical correlation analysis (CCA), and five subject-specific training methods, i.e.
View Article and Find Full Text PDF