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We isolated, identified, and characterised Bfsp1, a novel virulent phage of Cytobacillus firmus. Morphologically, Bfsp1 is similar to phi29-like phages. The linear, double-stranded DNA genome of Bfsp1 is 22,320 bp in length, has a GC content of 36.06%, and has 10-bp inverted terminal repeats. The genome contains 33 open reading frames, and functions of 15 of them were predicted. Comparative genome analysis showed that Bfsp1 is distinct from other known phages, and this was confirmed by phylogenetic analysis. Morphological, genomic, and phylogenetic data indicated that Bfsp1 is a novel member of the family Salasmaviridae.
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http://dx.doi.org/10.1007/s00705-022-05660-y | DOI Listing |
Urol J
September 2025
Affiliated Hospital of Nantong University, Emergency Department, Nantong, 226000, Jiangsu, China.
Purpose: Urosepsis, a condition caused by a urinary tract infection spreading to the bloodstream, has a complex epigenetic behavior in its cellular and molecular pathophysiology. The objective of this study was to identify relevant genes and signaling pathways in adult urosepsis through a bioinformatic analysis of differentially expressed genes (DEGs).
Materials And Methods: In this in-silico study, the GSE69528 dataset, containing 138 total RNA blood samples from patients with sepsis and uninfected controls, was obtained from the Gene Expression Omnibus (GEO) database.
Plant Commun
September 2025
School of Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK; Leibniz Institute of Plant Genetics and Crop Plant Research (IPK) Gatersleben, Seeland, Germany. Electronic address:
The coordination of floral developmental stages with the environment is important for reproductive success and the optimization of crop yields. The timing of different developmental stages contributes to final yield potential with optimal adaptation enabling development to proceed without being impacted by seasonal weather events, including frosts or end of season drought. Here we characterise the role of FLOWERING LOCUS T 3 (FT3) in hexaploid bread wheat (Triticum aestivum) during the early stages of floral development.
View Article and Find Full Text PDFBr J Cancer
September 2025
School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
Background: Studies examining the association of chronic kidney disease (CKD) with cancer risk have demonstrated conflicting results.
Methods: This was an individual participant data meta-analysis including 54 international cohorts contributing to the CKD Prognosis Consortium. Included cohorts had data on albuminuria [urine albumin-to-creatinine ratio (ACR)], estimated glomerular filtration rate (eGFR), overall and site-specific cancer incidence, and established risk factors for cancer.
Toxicol Appl Pharmacol
September 2025
Department of Pharmacological & Pharmaceutical Sciences, University of Houston College of Pharmacy, Houston, TX 77204, United States; Department of Pharmacy Practice & Translational Research, University of Houston College of Pharmacy, Houston, TX 77204, United States. Electronic address:
Vancomycin is one of the most commonly used parenteral antibiotics for treating drug-resistant bacterial infections, however, it is hindered by nephrotoxicity. We previously demonstrated that zileuton could delay the onset of vancomycin-associated nephrotoxicity in rats. Here, we sought to understand the mechanism(s) of zileuton renal protection.
View Article and Find Full Text PDFMod Pathol
September 2025
Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. Electronic address:
Uterine leiomyosarcoma (uLMS) is a rare and deadly gynecologic malignancy. uLMS is histologically heterogeneous and presents with a wide spectrum of tumor differentiation, with a broad range of genomic DNA instability, which can make the diagnosis and prognosis of uLMS challenging. Methylation has emerged as a useful molecular tool in tumor classification and diagnosis in certain neoplasms.
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