98%
921
2 minutes
20
Self-assembled peptide-based gels provide several advantages for technological applications. Recently, the co-assembly of gelators has been a strategy to modulate and tune gel properties and even implement stimuli-responsiveness. However, it still comprises limitations regarding the required library of compounds and outcoming properties. Hence, efforts have been made to combine peptide-based gels and (in)organic composites (e.g., magnetic nanoparticles, metal nanoparticles, liposomes, graphene, silica, clay, titanium dioxide, cadmium sulfide) to endow stimuli-responsive materials and achieve suitable properties in several fields ranging from optoelectronics to biomedical. Herein, we discuss the recent developments with composite peptide-based gels including the fabrication, tunability of gels' properties, and challenges on (bio)technological applications.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820439 | PMC |
http://dx.doi.org/10.3390/ijms24010186 | DOI Listing |
Chemistry
September 2025
Department of Pharmaceutical Sciences, University of Milan, Milano, 20133, Italy.
Hybrid biomolecules composed of short peptides and nucleic acid analogues can self-assemble and are good candidates to produce new materials thanks to their biocompatibility and versatility. The assembly occurs by exploiting hydrogen bonds and stacking interactions between nucleobases and amino acids. The organization of the molecules at the supramolecular level is dictated by the structure of the assembling units.
View Article and Find Full Text PDFNanomedicine (Lond)
September 2025
Fujian-Taiwan Science and Technology Cooperation Base of Biomedical Materials and Tissue Engineering, Engineering Research Center of Industrial Biocatalysis, College of Chemistry and Materials Science, Fujian Normal University, Fuzhou, Fujian, China.
Wound healing, particularly in chronic conditions such as diabetic ulcers, burns, and pressure injuries, represents a highly intricate and clinically challenging process. These wounds frequently exhibit persistent pathological inflammation, disrupting conventional healing trajectories and significantly compromising patient well-being. Consequently, the development of innovative therapeutic interventions is urgently needed.
View Article and Find Full Text PDFJ Colloid Interface Sci
December 2025
Biochemistry and Structural Biology, Lund University, PO Box 124, SE-221 00 Lund, Sweden.
The peptide Ac-KGSFSIQYTYHVD-CONH₂ (KD), derived from residues 37-49 of human semenogelin I, forms a pH-responsive hydrogel in an aqueous environment with tunable mechanical properties that evolve over time. We hypothesize that KD self-assembles into a hydrogel through a pH-dependent mechanism involving predominantly a change in histidine protonation state, leading to structural transformations that modulate its mechanical properties. Time-resolved nuclear magnetic resonance (NMR) spectroscopy and cryo-transmission electron microscopy (cryo-TEM) were employed to elucidate the gelation process and structural evolution of KD.
View Article and Find Full Text PDFNat Commun
August 2025
State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Enhancing the toughness of hydrogels for biomedical applications remains a challenge, as many toughening approaches often sacrifice biocompatibility or in situ applicability, thereby restricting their broader utility in biomedical contexts. Inspired by the intervertebral disk, here, we introduce a biocompatible toughening strategy using peptide-based rigid nanorods (PRNs) as backbone supports within gelatin methacryloyl (GelMA) hydrogels. PRNs are short polymers with exceptional rigidity, capable of covalent cross-linking with GelMA molecules at both ends.
View Article and Find Full Text PDFJ Colloid Interface Sci
December 2025
Department of Chemistry, Molecular Imaging and Photonics, KU Leuven - campus KULAK Kortrijk, Etienne Sabbelaan 53, 8500 Kortrijk, Belgium. Electronic address:
Peptide-based hydrogels formed by FmocFF (9-fluorenylmethoxycarbonyl-diphenylalanine) are established materials in tissue engineering, drug delivery, and bioelectronics. Although initial assembly processes and final states are relatively well known, the possibility of hidden, intermediate gel forms remains underexplored. Such "gel-to-gel" transitions may yield previously unnoticed polymorphs with distinct mechanical and structural features, expanding options for tuning gel functionality.
View Article and Find Full Text PDF